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Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- (2r,3s)-oxirane-2,3-dicarboxylic acid (132 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (75 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Gpcr complex of succinate receptor (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Gpcr complex (Complex from Homo sapiens)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-P2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ayj
Q-score: 0.484
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 3,5-dichloro-n-[(1-{[(4s)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide (431 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ML218
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayk
Q-score: 0.519
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 3,5-dichloro-n-{[(1r,5s,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide (369 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ACT-709478
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9ayl
Q-score: 0.531
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- N-{1-[(5-cyanopyridin-2-yl)methyl]-1h-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide (425 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
SARS-CoV-2 Omicron spike in complex with 5817 Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8khc
Q-score: 0.351
Wang Y, Zhang Z, Yang M, Xiong X, Yan Q, Cao L, Wei P, Zhang Y, Zhang L, Lv K, Chen J, Liu X, Zhao X, Xiao J, Zhang S, Zhu A, Gan M, Zhang J, Cai R, Zhuo J, Zhang Y, Rao H, Qu B, Zhang Y, Chen L, Dai J, Cheng L, Hu Q, Chen Y, Lv H, So RTY, Peiris M, Zhao J, Liu X, Mok CKP, Wang X, Zhao J
Cell Rep (2024) 43 pp. 113653-113653 [ DOI: doi:10.1016/j.celrep.2023.113653 Pubmed: 38175758 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Heavy chain of 5817 fab (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron spike in complex with 5817 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of 5817 fab (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
The interface structure of Omicron RBD binding to 5817 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8khd
Q-score: 0.393
Wang Y, Zhang Z, Yang M, Xiong X, Yan Q, Cao L, Wei P, Zhang Y, Zhang L, Lv K, Chen J, Liu X, Zhao X, Xiao J, Zhang S, Zhu A, Gan M, Zhang J, Cai R, Zhuo J, Zhang Y, Rao H, Qu B, Zhang Y, Chen L, Dai J, Cheng L, Hu Q, Chen Y, Lv H, So RTY, Peiris M, Zhao J, Liu X, Mok CKP, Wang X, Zhao J
Cell Rep (2024) 43 pp. 113653-113653 [ DOI: doi:10.1016/j.celrep.2023.113653 Pubmed: 38175758 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 5817 (11 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 5817 (13 kDa, Protein from Homo sapiens)
- The interface structure of omicron rbd binding to 5817 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8wa2
Q-score: 0.457
Huang J, Tao H, Chen J, Shen Y, Lei J, Pan J, Yan C, Yan N
Cell (2024) 187 pp. 1733-1744.e12 [ DOI: doi:10.1016/j.cell.2024.02.037 Pubmed: 38552612 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mastigoneme (Cellular component from Chlamydomonas reinhardtii)
- Mst1 (206 kDa, Protein from Chlamydomonas reinhardtii)
- Alpha-l-arabinofuranose (150 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Mstax (6 kDa, Protein from synthetic construct)
- Alpha-d-galactopyranose (180 Da, Ligand)