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Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y64
Q-score: 0.498
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ DOI: doi:10.1038/s41422-023-00779-2 Pubmed: 36806352 ]
- Scfv16 (Complex from Mus musculus)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5a-bound c5ar1 (Complex from Homo sapiens)
- C5a-bound c5ar1 in complex with gi heterotrimer (Complex)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7y65
Q-score: 0.438
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ DOI: doi:10.1038/s41422-023-00779-2 Pubmed: 36806352 ]
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- C5apep-bound c5ar1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- C5apep peptide (869 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C5apep-bound c5ar1 in complex with gi heterotrimer (Complex)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y66
Q-score: 0.478
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ DOI: doi:10.1038/s41422-023-00779-2 Pubmed: 36806352 ]
- Scfv16 (Complex from Mus musculus)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Bm213-bound c5ar1 (Complex from Homo sapiens)
- Bm213-bound c5ar1 in complex with gi heterotrimer (Complex)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Bm213 peptide (901 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7y67
Q-score: 0.494
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ DOI: doi:10.1038/s41422-023-00779-2 Pubmed: 36806352 ]
- Scfv16 (Complex from Mus musculus)
- C089 peptide (902 Da, Protein from synthetic construct)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C089-bound c5ar1-i116a in complex with gi heterotrimer (Complex)
- C089-bound c5ar1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)