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Cryo-EM structure of Cortactin-bound to Arp2/3 complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8tah
Q-score: 0.514
Fregoso FE, Boczkowska M, Rebowski G, Carman PJ, van Eeuwen T, Dominguez R
Nat Commun (2023) 14 pp. 6894-6894 [ DOI: doi:10.1038/s41467-023-42229-y Pubmed: 37898612 ]
- Src substrate cortactin (8 kDa, Protein from Mus musculus)
- Actin-related protein 2 (44 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Actin-related protein 3 (47 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 3 (20 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 4 (19 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 2 (34 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 1a (41 kDa, Protein from Bos taurus)
- Actin-related protein 2/3 complex subunit 5 (16 kDa, Protein from Bos taurus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cortactin nta bound to arp2/3 complex (223 kDa, Complex from Bos taurus)
Bovine complex I in the slack state at 3.5 A
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the active state at 3.1 A (Composite map)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the active state at 3.1 A (Hydrophlic domain)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the active state at 3.1 A (Proximal hydrophobic domain)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the active state at 3.1 A (Distal hydrophobic domain)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the presence of IM1761092, active class i (Composite map)
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7r41
Q-score: 0.686
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (17 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (15 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (14 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 subunit c2 (14 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (21 kDa, Protein from cattle)
- Nadh-ubiquinone oxidoreductase chain 4l (10 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (13 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (19 kDa, Protein from cattle)
- 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine (365 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (6 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (50 kDa, Protein from cattle)
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
- Cardiolipin (1 kDa, Ligand)
- Nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (27 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (12 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (9 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (21 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (11 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 subunit c1, mitochondrial (8 kDa, Protein from cattle)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (20 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (15 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (21 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (23 kDa, Protein from cattle)
- Iron/sulfur cluster (351 Da, Ligand)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from cattle)
- Nadh-ubiquinone oxidoreductase chain 2 (39 kDa, Protein from cattle)
- Flavin mononucleotide (456 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (17 kDa, Protein from cattle)
- Nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial (79 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (15 kDa, Protein from cattle)
- Myristic acid (228 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (39 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 5 (12 kDa, Protein from cattle)
- Nadh-ubiquinone oxidoreductase chain 6 (19 kDa, Protein from cattle)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 4 (52 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (16 kDa, Protein from cattle)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nadh-ubiquinone oxidoreductase chain 5 (68 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (8 kDa, Protein from cattle)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (52 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (21 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (11 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (11 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (16 kDa, Protein from cattle)
- Magnesium ion (24 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (30 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (42 kDa, Protein from cattle)
- Nadh-ubiquinone oxidoreductase chain 1 (35 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (12 kDa, Protein from cattle)
- Nadh-ubiquinone oxidoreductase chain 3 (13 kDa, Protein from cattle)
- Nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (23 kDa, Protein from cattle)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{s})-3-oxidanyltetradecanethioate (584 Da, Ligand)
- Nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (13 kDa, Protein from cattle)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
Bovine complex I in the presence of IM1761092, active class i (Consensus)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the presence of IM1761092, active class i (Hydophilic domain)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)
Bovine complex I in the presence of IM1761092, active class i (Proximal hydrophobic domain)
Bridges HR, Blaza JN, Yin Z, Chung I, Pollak MN, Hirst J
Science (2023) 379 pp. 351-357 [ Pubmed: 36701435 DOI: doi:10.1126/science.ade3332 ]
- Nadh ubiquinone oxidoreductase (complex i) (1 MDa, Complex from Bos taurus)