Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research. We appreciate your responses prior to closing of the survey on Monday 17th June.
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8dcr
Q-score: 0.593
Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 4095-4095 [ Pubmed: 35835792 DOI: doi:10.1038/s41467-022-31823-1 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Dobutamine (301 Da, Ligand)
- Endolysin,endolysin,beta-1 adrenergic receptor chimera (57 kDa, Protein from Meleagris gallopavo)
- Dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric gs-protein (Complex from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8dcs
Q-score: 0.645
Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 4095-4095 [ Pubmed: 35835792 DOI: doi:10.1038/s41467-022-31823-1 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- 4-{[(2s)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3h-indole-2-carbonitrile (287 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Endolysin,endolysin,beta-1 adrenergic receptor chimera (57 kDa, Protein from Meleagris gallopavo)
- Cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric gs-protein (Complex from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Lysophosphatidic acid receptor 1-Gi complex bound to LPA
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7td0
Q-score: 0.527
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 731-731 [ DOI: doi:10.1038/s41467-022-28417-2 Pubmed: 35136060 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl (9e)-octadec-9-enoate (436 Da, Ligand)
- Lysophosphatidic acid receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Complex of lysophosphatidic acid receptor 1 with g-protein and lpa (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Rattus norvegicus)
Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 7td1
Q-score: 0.496
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 731-731 [ DOI: doi:10.1038/s41467-022-28417-2 Pubmed: 35136060 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl (9e)-octadec-9-enoate (436 Da, Ligand)
- Lysophosphatidic acid receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Complex of lysophosphatidic acid receptor 1 with g-protein and lpa (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Rattus norvegicus)
Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7td2
Q-score: 0.506
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 731-731 [ DOI: doi:10.1038/s41467-022-28417-2 Pubmed: 35136060 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- (2r)-2-hydroxy-3-(phosphonooxy)propyl (9e)-octadec-9-enoate (436 Da, Ligand)
- Lysophosphatidic acid receptor 1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Complex of lysophosphatidic acid receptor 1 with g-protein and lpa (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Rattus norvegicus)
Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7td3
Q-score: 0.574
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 731-731 [ DOI: doi:10.1038/s41467-022-28417-2 Pubmed: 35136060 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sphingosine 1-phosphate receptor 1 (43 kDa, Protein from Homo sapiens)
- Complex of sphingosine-1-phosphate receptor 1 with g-protein and s1p (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Rattus norvegicus)
Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7td4
Q-score: 0.605
Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 731-731 [ DOI: doi:10.1038/s41467-022-28417-2 Pubmed: 35136060 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Complex of sphingosine-1-phosphate receptor 1 with g-protein and siponimod (Complex from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-[[4-[(~{e})-~{n}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{c}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid (516 Da, Ligand)
- Sphingosine 1-phosphate receptor 1 (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Rattus norvegicus)
Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7s0f
Q-score: 0.531
Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY
Nat Struct Mol Biol (2021) 28 pp. 936-944 [ DOI: doi:10.1038/s41594-021-00679-2 Pubmed: 34759376 ]
- Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric gi protein (146 kDa, Complex from Bos taurus)
- Beta1-adrenergic receptor (57 kDa, Protein from Meleagris gallopavo)
- Isoprenaline (211 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1, (43 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi/s chimera protein
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7s0g
Q-score: 0.409
Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY
Nat Struct Mol Biol (2021) 28 pp. 936-944 [ DOI: doi:10.1038/s41594-021-00679-2 Pubmed: 34759376 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short chimera (43 kDa, Protein from Bos taurus)
- Beta1-adrenergic receptor (57 kDa, Protein from Meleagris gallopavo)
- Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric gi/s chimera protein (146 kDa, Complex from Bos taurus)
- Isoprenaline (211 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)