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Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5oam
Q-score: 0.255
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker without nucleotide (Complex)
- Tublin, beta (Complex from Sus scrofa)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Tubulin, alpha (Complex from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Taxol (853 Da, Ligand)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 5ocu
Q-score: 0.26
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with amppnp (Complex)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Tubulin, alpha (Complex from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Tubulin, beta (Complex from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Taxol (853 Da, Ligand)
Molecular basis of human kinesin-8 function and inhibition
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Tubulin beta chain (Complex from sus scrofa)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene (297 Da, Ligand)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with its specific inhibitor btb-1 (Complex)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin alpha chain (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Taxol (853 Da, Ligand)
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5m5c
Q-score: 0.215
Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A
Nat Struct Mol Biol (2017) 24 pp. 931-943 [ Pubmed: 28991265 DOI: doi:10.1038/nsmb.3483 ]
- Camsap1-n1492a mutant ckk domain (Complex from homo sapiens)
- Tubulin alpha chain (48 kDa, Protein from Bos taurus)
- Calmodulin-regulated spectrin-associated protein 1 (13 kDa, Protein from Homo sapiens)
- Complex of two tubulin dimers with bound camsap1-n1492a mutant ckk domain (Complex)
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin dimer (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Taxol (853 Da, Ligand)
Microtubule-bound MKLP2 motor domain in the presence of ADP
Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A, Moores CA
eLife (2017) 6 [ DOI: doi:10.7554/eLife.27793 Pubmed: 28826477 ]
- Complex of 14pf microtubule with bound mklp2 motor domain in the presence of adp (Complex)
- Kinesin-like protein kif20a (Complex from Mus musculus)
- Taxol (853 Da, Ligand)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tubulin beta-2b chain (49 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha and beta chains (Complex from Bos taurus)
- Kinesin-like protein kif20a (56 kDa, Protein from Mus musculus)
Microtubule-bound MKLP2 motor domain in the with no nucleotide
Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A, Moores CA
eLife (2017) 6 [ DOI: doi:10.7554/eLife.27793 Pubmed: 28826477 ]
- Kinesin-like protein kif20a (Complex from Mus musculus)
- Tubulin beta-2b chain (49 kDa, Protein from Bovine)
- Taxol (853 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Complex of 13pf taxol-gdp microtubule with bound mklp2 motor domain with no-nucleotide (Complex)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin alpha chain (50 kDa, Protein from Bovine)
- Tubulin alpha and beta chains (Complex from Bos taurus)
- Kinesin-like protein kif20a (56 kDa, Protein from Mus musculus)
Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5nd4
Q-score: 0.148
Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A, Moores CA
eLife (2017) 6 [ DOI: doi:10.7554/eLife.27793 Pubmed: 28826477 ]
- Tubulin alpha chain (45 kDa, Protein from Bos taurus)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Taxol (853 Da, Ligand)
- Kinesin-like protein kif20a (Complex from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Complex of 14pf microtubule with bound mklp2 motor domain in the presence of adp.alfx (Complex)
- Magnesium ion (24 Da, Ligand)
- Tubulin alpha and beta chains (Complex from Bos taurus)
- Kinesin-like protein kif20a (56 kDa, Protein from Mus musculus)
Microtubule-bound MKLP2 motor domain in the presence of AMPPNP
Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A, Moores CA
eLife (2017) 6 [ DOI: doi:10.7554/eLife.27793 Pubmed: 28826477 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Tubulin alpha and beta chains (Complex)
- Tubulin beta-2b chain (49 kDa, Protein from Bovine)
- Taxol (853 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin alpha chain (50 kDa, Protein from Bovine)
- Kinesin-like protein kif20a (Complex from Bos taurus)
- Complex of 13pf microtubule with bound mklp2 motor domain in the presence of amppnp (Complex from Mus musculus)
- Kinesin-like protein kif20a (56 kDa, Protein from Mus musculus)
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Resolution: 5.3 Å
EM Method: Single-particle
Fitted PDBs: 5m50
Q-score: 0.175
Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A
Nat Struct Mol Biol (2017) 24 pp. 931-943 [ Pubmed: 28991265 DOI: doi:10.1038/nsmb.3483 ]
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Tubulin alpha chain (48 kDa, Protein from Bos taurus)
- Calmodulin-regulated spectrin-associated protein 3 (13 kDa, Protein from Mus musculus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Complex of two tubulin dimers with bound camsap3-ckk domain (Complex)
- Tubulin (Complex from Bos taurus)
- Camsap3-ckk domain (Complex from Mus musculus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Taxol (853 Da, Ligand)
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 5m54
Q-score: 0.147
Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A
Nat Struct Mol Biol (2017) 24 pp. 931-943 [ Pubmed: 28991265 DOI: doi:10.1038/nsmb.3483 ]
- Tubulin alpha chain (48 kDa, Protein from Bos taurus)
- Calmodulin-regulated spectrin-associated protein 1 (13 kDa, Protein from Homo sapiens)
- Complex of two tubulin dimers with bound camsap1-ckk domain (Complex)
- Tubulin (Complex from Bos taurus)
- Camsap1-ckk domain (Complex from Homo sapiens)
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Taxol (853 Da, Ligand)