Human GPR34 -Gi complex bound to S3E-LysoPS
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xbe
Q-score: 0.445
Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 902-902 [ DOI: doi:10.1038/s41467-024-45046-z Pubmed: 38326347 ]
- Human gpr34-gi complex bound to s3e-lysops (Complex)
- Probable g-protein coupled receptor 34 (45 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 34 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Scfv16 (Complex from Mus musculus)
- (2~{s})-2-azanyl-3-[[(2~{r})-1-ethoxy-3-[(~{z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid (551 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
ETB-eGt complex bound to endothelin-1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xgr
Q-score: 0.425
Oshima HS, Sano FK, Akasaka H, Iwama A, Shihoya W, Nureki O
Biochem Biophys Res Commun (2024) 693 pp. 149361-149361 [ Pubmed: 38128244 DOI: doi:10.1016/j.bbrc.2023.149361 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,egt-alpha (48 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
- Camelid antibody vhh fragment (17 kDa, Protein from Lama glama)
- Complex of endothelin-1, etb, egt trimer and nb35* (Complex from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Endothelin receptor type b (67 kDa, Protein from Homo sapiens)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8go9
Q-score: 0.46
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin2 (Complex from Bos taurus)
- Atypical chemokine receptor 2 (2 kDa, Protein from Homo sapiens)
- Fab30 (Complex from Mus musculus)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Peptide bound beta-arrestin2 in complex with fab30 (190 kDa, Complex)
- Atypical chemokine receptor 2 (Complex from Homo sapiens)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
Structure of beta-arrestin2 in complex with M2Rpp
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8j8r
Q-score: 0.543
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin2 (Complex from Bos taurus)
- Muscarinic acetylcholine receptor m2 (2 kDa, Protein from Homo sapiens)
- Beta-arrestin2 in complex with m2rpp (Complex)
- Fab30 (Complex from Mus musculus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
Structure of beta-arrestin2 in complex with D6Rpp (Local Refine)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8j8v
Q-score: 0.514
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin2 (Complex from Bos taurus)
- Beta-arrestin2 in complex with d6rpp (Complex)
- Atypical chemokine receptor 2 (2 kDa, Protein from Homo sapiens)
- Fab30 (Complex from Mus musculus)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Atypical chemokine receptor 2 (Complex from Homo sapiens)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j97
Q-score: 0.456
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
- Beta-arrestin1 (Complex from Bos taurus)
- Muscarinic acetylcholine receptor m2 (1 kDa, Protein from Homo sapiens)
- Beta-arrestin-1 (39 kDa, Protein from Bos taurus)
- Fab30 (Complex from Mus musculus)
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
- Muscarinic receptor (m2r) in complex with beta-arrestin1 (Complex)
- Fab30 heavy chain (12 kDa, Protein from Mus musculus)
Muscarinic receptor (M2R) in complex with beta-arrestin1 (Low resolution full map, Cross-linked)
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
Muscarinic receptor (M2R) in complex with beta-arrestin1 (Low resolution full map, non-crosslinked)
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jaf
Q-score: 0.368
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ Pubmed: 38175886 DOI: doi:10.1126/science.adj3347 ]
- Beta-arrestin1 (Complex from Bos taurus)
- Beta-arrestin-1 (40 kDa, Protein from Bos taurus)
- Fab30 (Complex from Mus musculus)
- Fab30 heavy chain (12 kDa, Protein from Mus musculus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Muscarinic acetylcholine receptor m2 (983 Da, Protein from Homo sapiens)
- Muscarinic receptor (m2r) in complex with beta-arrestin1 (Complex)
Human GPR34 -Gi complex bound to M1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8xbh
Q-score: 0.473
Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 902-902 [ DOI: doi:10.1038/s41467-024-45046-z Pubmed: 38326347 ]
- Probable g-protein coupled receptor 34 (45 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 34 (Complex from Homo sapiens)
- Human gpr34-gi complex bound to m1 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- (2~{s})-2-azanyl-3-[[(2~{r})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid (617 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)