Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Ribavirin
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8tz1
Q-score: 0.596
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- 1-(beta-d-ribofuranosyl)-1h-1,2,4-triazole-3-carboxamide (244 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in MSP2N2 nanodiscs, apo state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8tz2
Q-score: 0.555
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 8tz3
Q-score: 0.649
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8tz4
Q-score: 0.503
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with N-hydroxycytidine
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8tz5
Q-score: 0.559
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- N-hydroxycytidine (259 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with PSI-6206
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8tz6
Q-score: 0.555
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- 2'-deoxy-2'-fluoro-2'-methyluridine (260 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8tz7
Q-score: 0.53
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- N-hydroxy-5'-o-(2-methylpropanoyl)cytidine (329 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8tz8
Q-score: 0.504
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- N-hydroxy-5'-o-(2-methylpropanoyl)cytidine (329 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8tz9
Q-score: 0.387
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- N-hydroxy-5'-o-(2-methylpropanoyl)cytidine (329 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8tza
Q-score: 0.449
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) [ Pubmed: 38418906 DOI: doi:10.1038/s41589-024-01559-8 ]
- N-hydroxy-5'-o-(2-methylpropanoyl)cytidine (329 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)