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Cryo-EM structure of CDK2-cyclin A in complex with CDC25A
Rowland RJ, Korolchuk S, Salamina M, Ault JR, Hart S, Turkenburg JP, Blaza JN, Noble MEM, Endicott JA
To Be Published
- Cyclin-dependent kinase 2 (34 kDa, Protein from Homo sapiens)
- Trimeric complex of cdk2-cyclin a-cdc25a (86 kDa, Complex from Homo sapiens)
- M-phase inducer phosphatase 1 (22 kDa, Protein from Homo sapiens)
- Cyclin-a2 (30 kDa, Protein from Bos taurus)
Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j97
Q-score: 0.456
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Beta-arrestin1 (Complex from Bos taurus)
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Beta-arrestin-1 (39 kDa, Protein from Bos taurus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m2 (1 kDa, Protein from Homo sapiens)
- Muscarinic receptor (m2r) in complex with beta-arrestin1 (Complex)
- Fab30 (Complex from Mus musculus)
- Fab30 heavy chain (12 kDa, Protein from Mus musculus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jaf
Q-score: 0.368
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Fab30 heavy chain (12 kDa, Protein from Mus musculus)
- Beta-arrestin1 (Complex from Bos taurus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m2 (983 Da, Protein from Homo sapiens)
- Beta-arrestin-1 (40 kDa, Protein from Bos taurus)
- Muscarinic receptor (m2r) in complex with beta-arrestin1 (Complex)
- Fab30 (Complex from Mus musculus)
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8jpd
Q-score: 0.497
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Focused refinement structure of grk2 in ntsr1-grk2-galpha(q) complexes (Complex from Bos taurus)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Staurosporine (466 Da, Ligand)
Cryo-EM structure of bovine NTCP complexed with YN69202Fab
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7vae
Q-score: 0.4
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (38 kDa, Protein from Bos taurus)
- Ntcp (Complex from Mus musculus)
- Fab (Complex)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 6r4r
Q-score: 0.44
Roder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schroder GF
Nat Commun (2019) 10 pp. 3754-3754 [ Pubmed: 31434882 DOI: doi:10.1038/s41467-019-11320-8 ]
- Fibril of pi3k-sh3 domains (34 MDa, Complex from Bos taurus)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (9 kDa, Protein from Bos taurus)
Cryo-EM structure of the native rhodopsin dimer from rod photoreceptor cells
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6ofj
Q-score: 0.147
Zhao DY, Poge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K
J Biol Chem (2019) 294 pp. 14215-14230 [ DOI: doi:10.1074/jbc.RA119.010089 Pubmed: 31399513 ]
Resolution: 10.8 Å
EM Method: Single-particle
Fitted PDBs: 3izy
Q-score: 0.062
Yassin AS, Haque ME, Datta PP, Elmore K, Banavali NK, Spremulli LL, Agrawal RK
PNAS (2011) 108 pp. 3918-3923 [ Pubmed: 21368145 DOI: doi:10.1073/pnas.1017425108 ]
9 Angstrom Structure of an AMPPNP Microtubule-Kinesin5 Complex
Resolution: 9.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 2wbe
Q-score: 0.079
Bodey AJ, Kikkawa M, Moores CA
J Mol Biol (2009) 388 pp. 218-224 [ DOI: doi:10.1016/j.jmb.2009.03.008 Pubmed: 19285086 ]
- Microtubule (Protein from Bos taurus)
- Klp61f (42 kDa, Protein from Drosophila melanogaster)
- Microtubule-klp61f complex with amppnp (Sample)