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local refinement of SARS-CoV-2 spike/Nb4 complex with 2 RBDs up and 3 Nb4 bound
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8g7c
Q-score: 0.231
Ye G, Bu F, Pan R, Wen W, Mendoza A, Spiller B, Du L, Perlman S, Liu B, Li F
To Be Published
- Sars-cov-2 spike/nb4 complex with 2 rbds up and 3 nb4 (459 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Nanosota-4 (16 kDa, Protein from Vicugna pacos)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (136 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Nup93 in complex with 5-Nup93 inhibitory NB and 15-Nup93 tracking NB
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7zox
Q-score: 0.393
Sola Colom M, Fu Z, Gunkel P, Guttler T, Trakhanov S, Srinivasan V, Gregor K, Pleiner T, Gorlich D
EMBO J (2024) [ DOI: doi:10.1038/s44318-024-00081-w Pubmed: 38649536 ]
- Xnup93-nb2t (12 kDa, Protein from Vicugna pacos)
- Nuclear pore complex protein nup93 (74 kDa, Protein from Xenopus laevis)
- Nup93 in complex with 5-nup93 inhibitory nb and 15-nup93 tracking nb (100 kDa, Complex from Xenopus laevis, Vicugna pacos)
- Xhnup93-nb4i (13 kDa, Protein from Vicugna pacos)
human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8ci2
Q-score: 0.381
Prevost MS, Barilone N, Dejean de la Batie G, Pons S, Ayme G, England P, Gielen M, Bontems F, Pehau-Arnaudet G, Maskos U, Lafaye P, Corringer PJ
Nat Commun (2023) 14 pp. 5964-5964 [ Pubmed: 37749098 DOI: doi:10.1038/s41467-023-41734-4 ]
- Human alpha7 nicotinic acetylcholine receptor (Complex from Homo sapiens)
- Nanobody c4 (Complex from Vicugna pacos)
- Nanobody c4 (15 kDa, Protein from Vicugna pacos)
- Neuronal acetylcholine receptor subunit alpha-7 (44 kDa, Protein from Homo sapiens)
- Complex of the human alpha7 nicotinic acetylcholine receptor with the nanobody c4 and with nicotine (250 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Interface of SARS-CoV-2 WT Spike in complex with R15 Fab and P14 Nanobody
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7y0o
Q-score: 0.3
To Be Published
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Complex from Homo sapiens)
- Light chain of r15 (11 kDa, Protein from Homo sapiens)
- P14 (Complex)
- R15 (Complex from Vicugna pacos)
- P14 nanobody (13 kDa, Protein from Vicugna pacos)
- Water (18 Da, Ligand)
- Complex of sars-cov-2 spike in complex with r15-f7 and p14-f18-35 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r15 (12 kDa, Protein from Homo sapiens)
To Be Published
SARS-CoV-2 Spike in complex with biparatopic nanobody BP10
Pymm P, Redmond SJ, Dolezal O, Mordant F, Lopez E, Cooney JP, Davidson KC, Haycroft ER, Tan CW, Seneviratna R, Grimley SL, Purcell DFJ, Kent SJ, Wheatley AK, Wang LF, Leis A, Glukhova A, Pellegrini M, Chung AW, Subbarao K, Uldrich AP, Tham WH, Godfrey DI, Gherardin NA
iScience (2022) 25 pp. 105259-105259 [ DOI: doi:10.1016/j.isci.2022.105259 Pubmed: 36213007 ]
- Bp10 biparatopic nanobody (Complex from Vicugna pacos)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with biparatopic nanobody bp10 (1 MDa, Complex)
- Bp10 biparatopic nanobody (Protein from Vicugna pacos)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
Nanodisc reconstituted MsbA in complex with nanobodies, spin-labeled at position T68C
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7ph7
Q-score: 0.419
Galazzo L, Meier G, Januliene D, Parey K, De Vecchis D, Striednig B, Hilbi H, Schafer LV, Kuprov I, Moeller A, Bordignon E, Seeger MA
Sci Adv (2022) 8 pp. eabn6845-eabn6845 [ DOI: doi:10.1126/sciadv.abn6845 Pubmed: 36223470 ]
- Atp-binding transport protein multicopy suppressor of htrb (65 kDa, Protein from Escherichia coli)
- (2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-4-[(2~{r},3~{s},4~{s},5~{r},6~{r})-6-[(1~{s})-1,2-bis(oxidanyl)ethyl]-4-[(2~{r},3~{s},4~{s},5~{s},6~{r})-6-[(1~{s})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3,5-bis(oxidanyl)oxan-2-yl]oxy-2-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-4-[(3~{r})-3-nonanoyloxytetradecanoyl]oxy-5-[[(3~{r})-3-octanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{s},4~{s},5~{s},6~{r})-3-oxidanyl-5-[[(3~{r})-3-oxidanylnonanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-oxan-2-yl]methoxy]-5-oxidanyl-oxane-2-carboxylic acid (2 kDa, Ligand)
- Nb_msba#1 (12 kDa, Protein from Vicugna pacos)
- E. coli msba in complex with nanobody nb_msba#1, labeled with gd-dota at t68c (Complex from Escherichia coli)
- Gadolinium atom (157 Da, Ligand)
- (1~{r},4~{r},11~{s},14~{s},19~{z})-19-[2-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]ethylimino]-7,8,17,18-tetraoxa-1,4,11,14-tetrazatricyclo[12.6.2.2^{4,11}]tetracosane-6,9,16-trione (524 Da, Ligand)