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human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8cau
Q-score: 0.523
Prevost MS, Barilone N, Dejean de la Batie G, Pons S, Ayme G, England P, Gielen M, Bontems F, Pehau-Arnaudet G, Maskos U, Lafaye P, Corringer PJ
Nat Commun (2023) 14 pp. 5964-5964 [ Pubmed: 37749098 DOI: doi:10.1038/s41467-023-41734-4 ]
- Nanobody c4 (15 kDa, Protein from Vicugna pacos)
- Human alpha7 nicotinic acetylcholine receptor (Complex from Homo sapiens)
- Nanobody c4 (Complex from Vicugna pacos)
- Neuronal acetylcholine receptor subunit alpha-7 (55 kDa, Protein from Homo sapiens)
- (s)-3-(1-methylpyrrolidin-2-yl)pyridine (162 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of the human alpha7 nicotinic acetylcholine receptor withthe nanobody c4 and with nicotine (250 kDa, Complex from Homo sapiens)
Human alpha7 nicotinic receptor in complex with the E3 nanobody
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ce4
Q-score: 0.6
Prevost MS, Barilone N, Dejean de la Batie G, Pons S, Ayme G, England P, Gielen M, Bontems F, Pehau-Arnaudet G, Maskos U, Lafaye P, Corringer PJ
Nat Commun (2023) 14 pp. 5964-5964 [ Pubmed: 37749098 DOI: doi:10.1038/s41467-023-41734-4 ]
- Complex of the human alpha7 nicotinic acetylcholine receptor with the nanobody e3 (Complex from Homo sapiens)
- Human alpha7 nicotinic acetylcholine receptor (Complex from Homo sapiens)
- Nanobody e3 (Complex from Vicugna pacos)
- Nanobody e3 (15 kDa, Protein from Vicugna pacos)
- Neuronal acetylcholine receptor subunit alpha-7 (44 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ci1
Q-score: 0.566
Prevost MS, Barilone N, Dejean de la Batie G, Pons S, Ayme G, England P, Gielen M, Bontems F, Pehau-Arnaudet G, Maskos U, Lafaye P, Corringer PJ
Nat Commun (2023) 14 pp. 5964-5964 [ Pubmed: 37749098 DOI: doi:10.1038/s41467-023-41734-4 ]
- Nanobody e3 (15 kDa, Protein from Homo sapiens)
- Complex of the human alpha7 nicotinic acetylcholine receptor with the nanobody e3 (Complex from Homo sapiens)
- Human alpha7 nicotinic acetylcholine receptor (Complex from Homo sapiens)
- Nanobody e3 (Complex from Vicugna pacos)
- (s)-3-(1-methylpyrrolidin-2-yl)pyridine (162 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-7 (44 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 8ci2
Q-score: 0.381
Prevost MS, Barilone N, Dejean de la Batie G, Pons S, Ayme G, England P, Gielen M, Bontems F, Pehau-Arnaudet G, Maskos U, Lafaye P, Corringer PJ
Nat Commun (2023) 14 pp. 5964-5964 [ Pubmed: 37749098 DOI: doi:10.1038/s41467-023-41734-4 ]
- Human alpha7 nicotinic acetylcholine receptor (Complex from Homo sapiens)
- Nanobody c4 (Complex from Vicugna pacos)
- Nanobody c4 (15 kDa, Protein from Vicugna pacos)
- Neuronal acetylcholine receptor subunit alpha-7 (44 kDa, Protein from Homo sapiens)
- Complex of the human alpha7 nicotinic acetylcholine receptor with the nanobody c4 and with nicotine (250 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)