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SARS-CoV-2 Spike in complex with biparatopic nanobody BP10
Pymm P, Redmond SJ, Dolezal O, Mordant F, Lopez E, Cooney JP, Davidson KC, Haycroft ER, Tan CW, Seneviratna R, Grimley SL, Purcell DFJ, Kent SJ, Wheatley AK, Wang LF, Leis A, Glukhova A, Pellegrini M, Chung AW, Subbarao K, Uldrich AP, Tham WH, Godfrey DI, Gherardin NA
iScience (2022) 25 pp. 105259-105259 [ DOI: doi:10.1016/j.isci.2022.105259 Pubmed: 36213007 ]
- Bp10 biparatopic nanobody (Complex from Vicugna pacos)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with biparatopic nanobody bp10 (1 MDa, Complex)
- Bp10 biparatopic nanobody (Protein from Vicugna pacos)
- Sars-cov-2 spike (Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 RBD in complex with biparatopic nanobody BP10 local refinement
Pymm P, Redmond SJ, Dolezal O, Mordant F, Lopez E, Cooney JP, Davidson KC, Haycroft ER, Tan CW, Seneviratna R, Grimley SL, Purcell DFJ, Kent SJ, Wheatley AK, Wang LF, Leis A, Glukhova A, Pellegrini M, Chung AW, Subbarao K, Uldrich AP, Tham WH, Godfrey DI, Gherardin NA
iScience (2022) 25 pp. 105259-105259 [ DOI: doi:10.1016/j.isci.2022.105259 Pubmed: 36213007 ]
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with biparatopic nanobody bp10 (1 MDa, Complex)
- Bp10 biparatopic nanobody (Protein from Vicugna pacos)
- Sars-cov-2 rbd (Protein from Severe acute respiratory syndrome coronavirus 2)
- Bp10 biparatopic nanobody (Complex from Vicugna pacos)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 7lx5
Q-score: 0.478
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH
PNAS (2021) 118 [ Pubmed: 33893175 DOI: doi:10.1073/pnas.2101918118 ]
- Wnb 10 (13 kDa, Protein from Vicugna pacos)
- Sars-cov-2 spike protein receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Wnb 2 (14 kDa, Protein from Vicugna pacos)
- Neutralizing nanobodies wnb 2 and wnb 10 (Complex from Vicugna pacos)
- Spike glycoprotein (152 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Focused refinement of the sars-cov-2 spike protein receptor binding domain bound to neutralizing nanobodies wnb 2 and wnb 10 (Complex)
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH
PNAS (2021) 118 [ Pubmed: 33893175 DOI: doi:10.1073/pnas.2101918118 ]
- Cryo-em map of sars-cov-2 spike protein bound to neutralising nanobodies wnb2 and wnb10 (c3 symmetry) (Complex)
- Neutralising nanobodies wnb2 and wnb10 (Complex from Vicugna pacos)
- Wnb10 (Protein from Vicugna pacos)
- Wnb2 (Protein from Vicugna pacos)
- Sars-cov-2 spike protein (Complex from evere acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
Pymm P, Adair A, Chan LJ, Cooney JP, Mordant FL, Allison CC, Lopez E, Haycroft ER, O'Neill MT, Tan LL, Dietrich MH, Drew D, Doerflinger M, Dengler MA, Scott NE, Wheatley AK, Gherardin NA, Venugopal H, Cromer D, Davenport MP, Pickering R, Godfrey DI, Purcell DFJ, Kent SJ, Chung AW, Subbarao K, Pellegrini M, Glukhova A, Tham WH
PNAS (2021) 118 [ Pubmed: 33893175 DOI: doi:10.1073/pnas.2101918118 ]
- Neutralising nanobodies wnb2 and wnb10 (Complex from Vicugna pacos)
- Wnb2 (Protein from Vicugna pacos)
- Wnb10 (Protein from Vicugna pacos)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em map of sars-cov-2 spike protein in complex with neutralising nanobodies wnb2 and wnb10 (c1 symmetry) (Complex)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)