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GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vj6
Q-score: 0.323
Hale WD, Romero AM, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01328-0 ]
GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2
Resolution: 4.85 Å
EM Method: Single-particle
Fitted PDBs: 8vj7
Q-score: 0.218
Hale WD, Romero AM, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01328-0 ]
- Isoform flip of glutamate receptor 2 (89 kDa, Protein from Rattus norvegicus)
- 4-[(5s,8r)-8-methyl-6,7,8,9-tetrahydro-2h,5h-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline (293 Da, Ligand)
- Ampa receptor glua2 homotetramer (Complex from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) [ DOI: doi:10.1038/s41586-024-07475-0 Pubmed: 38778115 ]
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) [ DOI: doi:10.1038/s41586-024-07475-0 Pubmed: 38778115 ]
- Glutamate ionotropic receptor kainate type subunit 2 (Protein from Rattus norvegicus)
- Concanavalin a (Complex from Canavalia ensiformis)
- Full-length rat gluk2 tetramer in complex with two concanavalin a dimers (510 kDa, Complex)
- Glutamate receptor ionotropic, kainate 2 (Complex from Rattus norvegicus)
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) [ DOI: doi:10.1038/s41586-024-07475-0 Pubmed: 38778115 ]
- Full-length rat gluk2 tetramer in complex with one concanavalin a homodimer (460 kDa, Complex)
- Glutamate ionotropic receptor kainate type subunit 2 (Protein from Rattus norvegicus)
- Concanavalin a (Complex from Canavalia ensiformis)
- Glutamate receptor ionotropic, kainate 2 (Complex from Rattus norvegicus)
Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
Li C, Liu H, Li J, Zhu H, Fu W, Xu HE
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- (2~{s})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid (398 Da, Ligand)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
Li C, Liu H, Li J, Zhu H, Fu W, Xu HE
To Be Published
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ykx
Q-score: 0.563
Li C, Liu H, Li J, Zhu H, Fu W, Xu HE
To Be Published
- Maleic acid (116 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
To Be Published
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 3a,enhanced green fluorescent protein (137 kDa, Protein from Muromegalovirus G4)
- Triheteromeric nmda receptor glun1-glun2a-glun3a in complex with glycine, glutamate, a glun1-specific fab,and a glun2a-specific fab (Complex from Rattus norvegicus)
- Glun1-specific antibody fragment heavy chain (23 kDa, Protein from Mus musculus)
- Glun1-specific antibody fragment light chain (25 kDa, Protein from Mus musculus)
- Glun2a-specific antibody fragment light chain (23 kDa, Protein from Mus musculus)
- Glutamate receptor ionotropic, nmda 2a,enhanced green fluorescent protein (125 kDa, Protein from Muromegalovirus G4)
- Glun2a-specific antibody fragment heavy chain (24 kDa, Protein from Mus musculus)
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) [ DOI: doi:10.1038/s41586-024-07475-0 Pubmed: 38778115 ]
- Full-length rat gluk2 tetramer (410 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)