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Structure of Apo CXCR4/Gi complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8u4n
Q-score: 0.56
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Cholesterol (386 Da, Ligand)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Apo cxcr4/gi complex (Complex from Homo sapiens)
Structure of CXCL12-bound CXCR4/Gi complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8u4o
Q-score: 0.489
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Cholesterol (386 Da, Ligand)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cxcl12-bound cxcr4/gi complex (Complex from Homo sapiens)
- Stromal cell-derived factor 1 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
Structure of AMD3100-bound CXCR4/Gi complex
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8u4p
Q-score: 0.532
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Cholesterol (386 Da, Ligand)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Plerixafor (502 Da, Ligand)
- Amd3100-bound cxcr4/gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
Structure of REGN7663 Fab-bound CXCR4/Gi complex
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8u4q
Q-score: 0.487
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Regn7663 fab-bound cxcr4/gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
Structure of REGN7663-Fab bound CXCR4
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8u4r
Q-score: 0.554
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Regn7663 fab-bound cxcr4 (Complex from Homo sapiens)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
Structure of trimeric CXCR4 in complex with REGN7663 Fab
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8u4s
Q-score: 0.49
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- (2r)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9z)-octadec-9-enoate (674 Da, Ligand)
- Trimeric cxcr4 in complex with regn7663 fab (Complex from Homo sapiens)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)
Structure of tetrameric CXCR4 in complex with REGN7663 Fab
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8u4t
Q-score: 0.51
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Regn7663 fab heavy chain (25 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- (2r)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9z)-octadec-9-enoate (674 Da, Ligand)
- Tetrameric cxcr4 in complex with regn7663 fab (Complex from Homo sapiens)
- Regn7663 fab light chain (24 kDa, Protein from Homo sapiens)