Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research.
Structural basis of Integrator-mediated transcription regulation
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7pks
Q-score: 0.278
Fianu I, Chen Y, Dienemann C, Dybkov O, Linden A, Urlaub H, Cramer P
Science (2021) 374 pp. 883-887 [ Pubmed: 34762484 DOI: doi:10.1126/science.abk0154 ]
- Dsif (Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit f (14 kDa, Protein from domestic pig)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit (217 kDa, Protein from domestic pig)
- Non-template dna (Complex from Human immunodeficiency virus 1)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Dna template (14 kDa, DNA from Human immunodeficiency virus 1)
- Rna_pol_l_2 domain-containing protein (13 kDa, Protein from domestic pig)
- Negative elongation factor a (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Rna polymerase ii subunit k (7 kDa, Protein from domestic pig)
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from domestic pig)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from domestic pig)
- Human integrator-pp2a complex (Complex from Homo sapiens)
- Tar rna (5 kDa, RNA from Human immunodeficiency virus 1)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Negative elongation factor b (68 kDa, Protein from Homo sapiens)
- Negative elongation factor e (1 kDa, Protein from Homo sapiens)
- Template dna (Complex from Human immunodeficiency virus 1)
- Unknown (2 kDa, Protein from Homo sapiens)
- Non-template dna (14 kDa, DNA from Human immunodeficiency virus 1)
- Rpbi c-terminal domain peptide (1 kDa, Protein from domestic pig)
- Rna (Complex from Human immunodeficiency virus 1)
- Nelf (Complex from Homo sapiens)
- Rna polymerase ii subunit d (16 kDa, Protein from domestic pig)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from domestic pig)
- Pol ii-ec (Complex from Sus scrofa domesticus)
- Manganese (ii) ion (54 Da, Ligand)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from domestic pig)
- Negative elongation factor c/d (68 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (106 kDa, Protein from Homo sapiens)
- Transcription elongation factor spt5 (121 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from domestic pig)
- Pec-integrator-pp2a complex (1 MDa, Complex)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from domestic pig)
- Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from domestic pig)
Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7b7u
Q-score: 0.483
Fianu I, Dienemann C, Aibara S, Schilbach S, Cramer P
Commun Biol (2021) 4 pp. 606-606 [ DOI: doi:10.1038/s42003-021-02088-z Pubmed: 34021257 ]
- Dna-directed rna polymerase ii (Complex from Sus scrofa domesticus)
- Dna-directed rna polymerase ii subunit rpb3 (30 kDa, Protein from domestic pig)
- Dna-directed rna polymerase ii subunit f (14 kDa, Protein from domestic pig)
- Zinc ion (65 Da, Ligand)
- Putative rna polymerase ii subunit b1 ctd phosphatase rpap2 (Complex from Homo sapiens)
- Rna polymerase ii -rpap2 complex (Complex)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from domestic pig)
- Dna-directed rna polymerase subunit (217 kDa, Protein from domestic pig)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from domestic pig)
- Rna_pol_l_2 domain-containing protein (13 kDa, Protein from domestic pig)
- Unknown (2 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from domestic pig)
- Putative rna polymerase ii subunit b1 ctd phosphatase rpap2 (69 kDa, Protein from Homo sapiens)
- Uncharacterized protein (7 kDa, Protein from domestic pig)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from domestic pig)
- Rna polymerase ii subunit k (7 kDa, Protein from domestic pig)