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Structure of Integrator-PP2A-SOSS-CTD post-termination complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8rbz
Q-score: 0.293
Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P
Nature (2024) 629 pp. 219-227 [ DOI: doi:10.1038/s41586-024-07269-4 Pubmed: 38570683 ]
- Integrator-pp2a complex and nabp2 and inip (Complex from Homo sapiens)
- Unk-unk-unk-unk-unk-unk-unk-unk-unk (783 Da, Protein from Sus scrofa)
- Soss complex subunit c (11 kDa, Protein from Homo sapiens)
- Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Rna polymerase ii c-terminal domain peptides (Complex from Sus scrofa)
- Integrator complex subunit 3 (118 kDa, Protein from Homo sapiens)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (107 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Post-termination complex (1 MDa, Complex)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Soss complex subunit b1 (22 kDa, Protein from Homo sapiens)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase subunit (1 kDa, Protein from Sus scrofa)
- Dss1 (3 kDa, Protein from Trichoplusia ni)
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Dss1 (Complex from Trichoplusia ni)
Structure of Integrator-PP2A complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8rc4
Q-score: 0.036
Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P
Nature (2024) 629 pp. 219-227 [ DOI: doi:10.1038/s41586-024-07269-4 Pubmed: 38570683 ]
- Manganese (ii) ion (54 Da, Ligand)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (107 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (65 kDa, Protein from Homo sapiens)
- Integrator complex subunit 13 (80 kDa, Protein from Homo sapiens)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Integrator-pp2a complex (Complex from Homo sapiens)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
- Dss1 (3 kDa, Protein from Trichoplusia ni)
- Integrator-pp2a complex (1 MDa, Complex)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 15 (50 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Integrator complex subunit 14 (57 kDa, Protein from Homo sapiens)
- Integrator complex subunit 10 (82 kDa, Protein from Homo sapiens)
- Dss1 (Complex from Trichoplusia ni)
- Integrator complex subunit 6 (101 kDa, Protein from Homo sapiens)
Resolution: 18.0 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8q6t
Q-score: 0.055
Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S
Nature (2023) 623 pp. 863-871 [ Pubmed: 37914933 DOI: doi:10.1038/s41586-023-06690-5 ]
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (18 kDa, Protein from Mus musculus)
- Myosin-7 (223 kDa, Protein from Mus musculus)
- Relaxed thick filament; a-band region; c-type super-repeat (Cell from Mus musculus)
- Myosin binding protein c, cardiac (44 kDa, Protein from Mus musculus)
- Titin (118 kDa, Protein from Mus musculus)
- Myosin light chain 3 (17 kDa, Protein from Mus musculus)
Cryo-EM structure of full-length Myosin Va in the autoinhibited state
Resolution: 4.78 Å
EM Method: Single-particle
Fitted PDBs: 7yv9
Q-score: 0.189
Niu F, Liu Y, Sun K, Xu S, Dong J, Yu C, Yan K, Wei Z
Sci Adv (2022) 8 pp. eadd4187-eadd4187 [ Pubmed: 36490350 DOI: doi:10.1126/sciadv.add4187 ]
- Myosin va and calmodulin complex (630 kDa, Complex from Mus musculus)
- Unconventional myosin-va (212 kDa, Protein from Mus musculus)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
The structure of human Integrator-PP2A complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7cun
Q-score: 0.35
Zheng H, Qi Y, Hu S, Cao X, Xu C, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y
Science (2020) 370 [ DOI: doi:10.1126/science.abb5872 Pubmed: 33243860 ]
- Pp2a (Complex from Homo sapiens)
- Pp2a-c (35 kDa, Protein from Homo sapiens)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Unknown (50 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (106 kDa, Protein from Homo sapiens)
- Integrator complex subunit 1, 2, 4, 5, 6, 7, 8, 9, 11 (Complex from Homo sapiens)
- Human integrator-pp2a complex (Complex)
- Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Unknown subunit (Complex from Homo sapiens)
- Pp2a-a (66 kDa, Protein from Homo sapiens)