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Microtubule complexed with Kif15 motor domain. Symmetrised asymmetric unit
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6zpi
Q-score: 0.238
Atherton J, Hummel JJ, Olieric N, Locke J, Pena A, Rosenfeld SS, Steinmetz MO, Hoogenraad CC, Moores CA
eLife (2020) 9 [ DOI: doi:10.7554/eLife.61481 Pubmed: 33252036 ]
- Tubulin alpha-1b chain (48 kDa, Protein from Pig)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Microtubule (Complex from Sus scrofa)
- Tubulin beta chain (48 kDa, Protein from Pig)
- Magnesium ion (24 Da, Ligand)
- Kif15 motor domain (Complex from Homo sapiens)
- Taxol (853 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kif15 motor domain (amppnp bound) complexed with microtubule. symmetrised asymmetric unit. (72 kDa, Complex)
- Kinesin-like protein kif15 (41 kDa, Protein from Homo sapiens)
Human kinesin-5 motor domain in the AMPPNP state bound to microtubules
Resolution: 6.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 6ta4
Q-score: 0.156
Pena A, Sweeney A, Cook AD, Topf M, Moores CA
Structure (2020) 28 pp. 450-457.e5 [ DOI: doi:10.1016/j.str.2020.01.013 Pubmed: 32084356 ]
- Amppnp bound human eg5 motor domain in complex with alpha/beta tubulin (Complex from Sus scrofa)
- Amppnp bound human eg5 motor domain in complex with alpha/beta tubulin (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Kinesin-like protein kif11 (43 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Amppnp bound human eg5 motor domain in complex with alpha/beta tubulin (Complex)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Tubulin beta chain (48 kDa, Protein from Sus scrofa)
- Tubulin alpha-1b chain (48 kDa, Protein from Sus scrofa)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5oam
Q-score: 0.255
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ Pubmed: 29078367 DOI: doi:10.1073/pnas.1712169114 ]
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker without nucleotide (Complex)
- Taxol (853 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Tublin, beta (Complex from Sus scrofa)
- Tubulin, alpha (Complex from Bos taurus)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 5ocu
Q-score: 0.26
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ Pubmed: 29078367 DOI: doi:10.1073/pnas.1712169114 ]
- Zinc ion (65 Da, Ligand)
- Taxol (853 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin, beta (Complex from Sus scrofa)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Tubulin, alpha (Complex from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with amppnp (Complex)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
Molecular basis of human kinesin-8 function and inhibition
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ Pubmed: 29078367 DOI: doi:10.1073/pnas.1712169114 ]
- Tubulin beta chain (Complex from sus scrofa)
- Taxol (853 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene (297 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with its specific inhibitor btb-1 (Complex)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Tubulin alpha chain (Complex from Bos taurus)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)