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HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6qus
Q-score: 0.454
Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores CA
Nat Commun (2019) 10 pp. 5236-5236 [ DOI: doi:10.1038/s41467-019-13247-6 Pubmed: 31748546 ]
- Taxol (853 Da, Ligand)
- Tubulin (Complex from Homo sapiens)
- Calmodulin-regulated spectrin-associated protein 1 (19 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Calmodulin-regulated spectrin-associated protein 1 (Complex from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Hsckk (human camsap1) decorated 13pf taxol-gdp microtubule (Complex)
NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6quy
Q-score: 0.434
Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores CA
Nat Commun (2019) 10 pp. 5236-5236 [ DOI: doi:10.1038/s41467-019-13247-6 Pubmed: 31748546 ]
- Taxol (853 Da, Ligand)
- Ngckk (n.gruberi ckk) decorated 13pf taxol-gdp microtubule (Complex)
- Tubulin (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- N.gruberi ckk (Complex from Naegleria gruberi)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Ckk domain protein (20 kDa, Protein from Naegleria gruberi)
NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6qve
Q-score: 0.435
Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores CA
Nat Commun (2019) 10 pp. 5236-5236 [ DOI: doi:10.1038/s41467-019-13247-6 Pubmed: 31748546 ]
- Predicted protein (20 kDa, Protein from Naegleria gruberi)
- Taxol (853 Da, Ligand)
- Tubulin (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Beta1-tubulin (49 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ngckk (naegleria gruberi ckk) decorated 14pf taxol-gdp microtubule (Complex)
- Naegleria gruberi ckk (Complex from Naegleria gruberi)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6qvj
Q-score: 0.429
Atherton J, Luo Y, Xiang S, Yang C, Rai A, Jiang K, Stangier M, Vemu A, Cook AD, Wang S, Roll-Mecak A, Steinmetz MO, Akhmanova A, Baldus M, Moores CA
Nat Commun (2019) 10 pp. 5236-5236 [ DOI: doi:10.1038/s41467-019-13247-6 Pubmed: 31748546 ]
- Tubilin (Complex from Homo sapiens)
- Taxol (853 Da, Ligand)
- Calmodulin-regulated spectrin-associated protein 1 (19 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Hsckk (human camsap1) decorated 14pf taxol-gdp microtubule (Complex)
- Tubulin beta chain (49 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin alpha-1b chain (50 kDa, Protein from Homo sapiens)
- Camsap1 (Complex from Homo sapiens)
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 5m5c
Q-score: 0.215
Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A
Nat Struct Mol Biol (2017) 24 pp. 931-943 [ DOI: doi:10.1038/nsmb.3483 Pubmed: 28991265 ]
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Tubulin dimer (Complex from Bos taurus)
- Taxol (853 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Camsap1-n1492a mutant ckk domain (Complex from homo sapiens)
- Tubulin alpha chain (48 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- Calmodulin-regulated spectrin-associated protein 1 (13 kDa, Protein from Homo sapiens)
- Complex of two tubulin dimers with bound camsap1-n1492a mutant ckk domain (Complex)
- Guanosine-5'-diphosphate (443 Da, Ligand)
Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins
Resolution: 5.3 Å
EM Method: Single-particle
Fitted PDBs: 5m50
Q-score: 0.175
Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A
Nat Struct Mol Biol (2017) 24 pp. 931-943 [ DOI: doi:10.1038/nsmb.3483 Pubmed: 28991265 ]
- Tubulin (Complex from Bos taurus)
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Camsap3-ckk domain (Complex from Mus musculus)
- Taxol (853 Da, Ligand)
- Tubulin alpha chain (48 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Complex of two tubulin dimers with bound camsap3-ckk domain (Complex)
- Calmodulin-regulated spectrin-associated protein 3 (13 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)