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CXCR3-DNGi complex activated by CXCL11
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hnk
Q-score: 0.532
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- C-x-c motif chemokine 11 (11 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cxcr3-cxcl11-dngi-scfv16 (Complex from Homo sapiens)
CXCR3-DNGi complex activated by PS372424
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8hnl
Q-score: 0.548
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- Cxcr3-ps372424-dngi-scfv16 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- (3s)-n-[(2s)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1h-isoquinoline-3-carboxamide (588 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
CXCR3-DNGi complex activated by VUF11222
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8hnm
Q-score: 0.546
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- Cholesterol (386 Da, Ligand)
- Cxcr3-vuf11222-dngi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- [4-(2-bromophenyl)phenyl]methyl-[[(1r,5s)-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl]-dimethyl-azanium (425 Da, Ligand)
CXCR3-DNGi complex activated by CXCL10
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8k2x
Q-score: 0.516
Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H
Cell Discov (2023) 9 pp. 119-119 [ Pubmed: 38012179 DOI: doi:10.1038/s41421-023-00617-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- C-x-c motif chemokine 10 (10 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Oplophorus gracilirostris)
- Cholesterol (386 Da, Ligand)
- Cxcr3-cxcl10-dngi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7xy6
Q-score: 0.468
Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G
Sci Adv (2022) 8 pp. eadd3709-eadd3709 [ DOI: doi:10.1126/sciadv.add3709 Pubmed: 36563137 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,adenosine receptor a2b,lgbit (Complex from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Adenosine receptor bound to an agonist in complex with g protein obtained by cryo-em (Complex from Homo sapiens)
- 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide (379 Da, Ligand)
- Soluble cytochrome b562,adenosine receptor a2b,lgbit (69 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7xy7
Q-score: 0.443
Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G
Sci Adv (2022) 8 pp. eadd3709-eadd3709 [ DOI: doi:10.1126/sciadv.add3709 Pubmed: 36563137 ]
- Soluble cytochrome b562,adenosine receptor (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- N-ethyl-5'-carboxamido adenosine (308 Da, Ligand)
- Soluble cytochrome b562,adenosine receptor a2b,lgbit (69 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Adenosine receptor a2b bound to a non-selective agonist in complex with g protein obtained by cryo-em (Complex from Homo sapiens)
- G protein (Complex from Homo sapiens)