Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research.
yeast cytoplasmic exosome-Ski2 complex degrading a RNA substrate
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8qcf
Q-score: 0.603
Keidel A, Kogel A, Reichelt P, Kowalinski E, Schafer IB, Conti E
Mol Cell (2023) 83 pp. 4093-4105.e7 [ DOI: doi:10.1016/j.molcel.2023.09.037 Pubmed: 37879335 ]
- Yeast cytoplasmic exosome-ski2 complex degrading a rna substrate (Complex from Saccharomyces cerevisiae)
- Exosome complex component mtr3 (27 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component ski6 (27 kDa, Protein from Saccharomyces cerevisiae)
- Rna (5'hairpin 60u) (24 kDa, RNA from Saccharomyces cerevisiae)
- Exosome complex component rrp40 (26 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp42 (29 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component csl4 (31 kDa, Protein from Saccharomyces cerevisiae)
- Superkiller protein 7 (39 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp43 (44 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp4 (39 kDa, Protein from Saccharomyces cerevisiae)
- Rrp46 isoform 1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Antiviral helicase ski2 (117 kDa, Protein from Saccharomyces cerevisiae)
- Exosome complex component rrp45 (34 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Exosome complex exonuclease dis3 (114 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8bgu
Q-score: 0.321
Castillo Duque de Estrada NM, Thoms M, Flemming D, Hammaren HM, Buschauer R, Ameismeier M, Bassler J, Beck M, Beckmann R, Hurt E
Nat Struct Mol Biol (2023) 30 pp. 1119-1131 [ Pubmed: 37291423 DOI: doi:10.1038/s41594-023-01006-7 ]
- 60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
- 5s rrna (38 kDa, RNA from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase mdm2 (55 kDa, Protein from Homo sapiens)
- Human mdm2-5s rnp (Complex from Homo sapiens)
Structure of USP14-bound human 26S proteasome in state EA2.1_UBL
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w39
Q-score: 0.43
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- Usp14 (Complex)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Substrate (Complex from Homo sapiens)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Substrate (913 Da, Protein from Saccharomyces cerevisiae)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7w3a
Q-score: 0.39
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- Usp14 (Complex)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Substrate (Complex from Homo sapiens)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Substrate (2 kDa, Protein from Saccharomyces cerevisiae)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7w3b
Q-score: 0.336
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Homo sapiens)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- Ed5_usp14 (Complex from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Substrate (Complex)
- Substrate (2 kDa, Protein from Saccharomyces cerevisiae)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Structure of USP14-bound human 26S proteasome in substrate-engaged state ED0_USP14
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7w3c
Q-score: 0.384
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Homo sapiens)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- Substrate (3 kDa, Protein from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Substrate (Complex)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Usp14 (Complex from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Structure of USP14-bound human 26S proteasome in substrate-engaged state ED1_USP14
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7w3f
Q-score: 0.399
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- Usp14 (Complex)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Substrate (Complex from Homo sapiens)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- Substrate (3 kDa, Protein from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Saccharomyces cerevisiae)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.0_USP14
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w3g
Q-score: 0.376
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Homo sapiens)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Substrate (Complex)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Usp14 (Complex from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Substrate (2 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w3h
Q-score: 0.43
Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y
Nature (2022) 605 pp. 567-574 [ DOI: doi:10.1038/s41586-022-04671-8 Pubmed: 35477760 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome (Complex from Homo sapiens)
- 26s proteasome (1 MDa, Complex from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)
- Substrate (3 kDa, Protein from Saccharomyces cerevisiae)
- 26s proteasome regulatory subunit 10b (45 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Substrate (Complex)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Isoform 2 of 26s proteasome regulatory subunit 8 (44 kDa, Protein from Homo sapiens)
- Usp14 (Complex from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- Ubiquitin carboxyl-terminal hydrolase 14 (56 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Isoform long of proteasome subunit alpha type-1 (30 kDa, Protein from Homo sapiens)
Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome, Dhr1-Dim1)
Lau B, Cheng J, Flemming D, La Venuta G, Berninghausen O, Beckmann R, Hurt E
Mol Cell (2021) 81 pp. 293-303.e4 [ Pubmed: 33326748 DOI: doi:10.1016/j.molcel.2020.11.009 ]