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Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8twe
Q-score: 0.592
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ DOI: doi:10.1038/s41586-023-06870-3 Pubmed: 38123684 ]
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8twi
Q-score: 0.499
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ DOI: doi:10.1038/s41586-023-06870-3 Pubmed: 38123684 ]
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Fe (iii) ion (55 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PP2A:B55-FAM122A complex
Resolution: 2.79961 Å
EM Method: Single-particle
Fitted PDBs: 8so0
Q-score: 0.561
Padi SKR, Vos MR, Godek RJ, Fuller JR, Kruse T, Hein JB, Nilsson J, Kelker MS, Page R, Peti W
Nature (2024) 625 pp. 195-203 [ DOI: doi:10.1038/s41586-023-06870-3 Pubmed: 38123684 ]
- Quadruple complex of pp2a:b55 (pp2aa:pp2ac:b55) bound to fam122a (Complex)
- Fe (iii) ion (55 Da, Ligand)
- Serine/threonine-protein phosphatase 2a 55 kda regulatory subunit b alpha isoform (52 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ppp2r1a-ppp2r2a-interacting phosphatase regulator 1 (10 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform (64 kDa, Protein from Homo sapiens)
- Serine/threonine-protein phosphatase 2a catalytic subunit alpha isoform (35 kDa, Protein from Homo sapiens)
Cryo-EM Structure of Human Serine Hydroxymethyltransferase, isoform 2 (SHMT2)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qi7
Q-score: 0.598
Rutkiewicz M, Tran LH, Ruszkowski M
To Be Published
- Water (18 Da, Ligand)
- Serine hydroxymethyltransferase, mitochondrial (52 kDa, Protein from Homo sapiens)
- Shmt2 in the form of plp internal aldimine (Complex from Homo sapiens)
CryoEM Structure INO80core Hexasome complex composite map state1
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8oo7
Q-score: 0.556
Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S
Science (2023) 381 pp. 313-319 [ Pubmed: 37384673 DOI: doi:10.1126/science.adf6287 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ino80 core module in complex with hexasome (861 kDa, Complex)
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Histone h2b (13 kDa, Protein from Homo sapiens)
- Dna strand 1 (69 kDa, DNA from synthetic construct)
- Dna (Complex from Synthetic construct)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Dna strand 2 (70 kDa, DNA from synthetic construct)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Actin-related protein 5 (87 kDa, Protein from Thermochaetoides thermophila)
- Ruvb-like protein 1 (50 kDa, Protein from Thermochaetoides thermophila)
- Chromatin remodeler ino80 (Complex from Thermochaetoides thermophila)
- Chromatin-remodeling complex subunit ies6 (23 kDa, Protein from Thermochaetoides thermophila)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromatin-remodeling atpase ino80 (130 kDa, Protein from Thermochaetoides thermophila)
- Ino eighty subunit 2 (53 kDa, Protein from Thermochaetoides thermophila)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Ruvb-like protein 2 (53 kDa, Protein from Thermochaetoides thermophila)
- Magnesium ion (24 Da, Ligand)
- Histones (Complex from Homo sapiens)
CryoEM Structure INO80core Hexasome complex Hexasome refinement state1
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8ooa
Q-score: 0.525
Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S
Science (2023) 381 pp. 313-319 [ Pubmed: 37384673 DOI: doi:10.1126/science.adf6287 ]
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Dna strand 1 (69 kDa, DNA from synthetic construct)
- Histone h2b (13 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Ino80 core module in complex with hexasome (861 kDa, Complex from Thermochaetoides thermophila)
- Dna strand 2 (70 kDa, DNA from synthetic construct)
INO80 core bound to hexasome composite map of state 2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8oop
Q-score: 0.554
Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S
Science (2023) 381 pp. 313-319 [ Pubmed: 37384673 DOI: doi:10.1126/science.adf6287 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ino80 core module in complex with hexasome (861 kDa, Complex)
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Dna strand 1 (69 kDa, DNA from synthetic construct)
- Histone h2b (13 kDa, Protein from Homo sapiens)
- Dna (Complex from Synthetic construct)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Dna strand 2 (70 kDa, DNA from synthetic construct)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Actin-related protein 5 (87 kDa, Protein from Thermochaetoides thermophila)
- Ruvb-like protein 1 (50 kDa, Protein from Thermochaetoides thermophila)
- Chromatin remodeler ino80 (Complex from Thermochaetoides thermophila)
- Chromatin-remodeling complex subunit ies6 (23 kDa, Protein from Thermochaetoides thermophila)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromatin-remodeling atpase ino80 (130 kDa, Protein from Thermochaetoides thermophila)
- Ino eighty subunit 2 (53 kDa, Protein from Thermochaetoides thermophila)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Ruvb-like protein 2 (53 kDa, Protein from Thermochaetoides thermophila)
- Magnesium ion (24 Da, Ligand)
- Histones (Complex from Homo sapiens)
CryoEM Structure INO80core Hexasome complex ATPase-hexasome refinement state 2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8oos
Q-score: 0.494
Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S
Science (2023) 381 pp. 313-319 [ Pubmed: 37384673 DOI: doi:10.1126/science.adf6287 ]
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Dna strand 1 (69 kDa, DNA from synthetic construct)
- Histone h2b (13 kDa, Protein from Homo sapiens)
- Ino80 (Complex from Thermochaetoides thermophila)
- Chromatin-remodeling atpase ino80 (130 kDa, Protein from Thermochaetoides thermophila)
- Dna (Complex from Synthetic construct)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Dna strand 2 (70 kDa, DNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Histones (Complex from Homo sapiens)
- Ino80 core module in complex with hexasome (861 kDa, Complex)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8g8f
Q-score: 0.573
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM
J Biol Chem (2023) 299 pp. 105012-105012 [ Pubmed: 37414152 DOI: doi:10.1016/j.jbc.2023.105012 ]
- Inosine-5'-monophosphate dehydrogenase 2 (56 kDa, Protein from Homo sapiens)
- Filament of inosine-5'-monophosphate dehydrogenase 2 - l245p mutant, bound to atp, imp, and nad+ (Complex from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inosinic acid (348 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g9b
Q-score: 0.529
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM
J Biol Chem (2023) 299 pp. 105012-105012 [ Pubmed: 37414152 DOI: doi:10.1016/j.jbc.2023.105012 ]
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Inosine-5'-monophosphate dehydrogenase 2 (56 kDa, Protein from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inosinic acid (348 Da, Ligand)
- Filament of inosine-5'-monophosphate dehydrogenase 2 - l245p mutant, bound to gtp, atp, imp, and nad+ (Complex from Homo sapiens)