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Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7z24
Q-score: 0.494
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Hiv-1 reverse transcriptase with a dna aptamer in complex with nevirapine (Complex from Human immunodeficiency virus type 1 BH10)
- 11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (266 Da, Ligand)
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 7z29
Q-score: 0.463
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit with e138k mutation (Complex from Human immunodeficiency virus type 1 BH10)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- P51 rt (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- 11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (266 Da, Ligand)
- Hiv-1 reverse transcriptase p66 subunit with m184i mutation (Complex from Human immunodeficiency virus type 1 BH10)
- Nnrti resistant m184i/e138k mutant hiv-1 reverse transcriptase with a dna aptamer in complex with nevirapine (Complex from Human immunodeficiency virus type 1 BH10)
Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with rilpivirine
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 7z2d
Q-score: 0.452
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase with a dna aptamer in complex with rilpivirine (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- 4-{[4-({4-[(e)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile (366 Da, Ligand)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7z2e
Q-score: 0.448
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit with e138k mutation (Complex from Human immunodeficiency virus type 1 BH10)
- 4-{[4-({4-[(e)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile (366 Da, Ligand)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- P51 rt (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p66 subunit with m184i mutation (Complex from Human immunodeficiency virus type 1 BH10)
- Nnrti resistant m184i/e138k mutant hiv-1 reverse transcriptase with a dna aptamer in complex with rilpivirine (Complex from Human immunodeficiency virus type 1 BH10)
Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7z2g
Q-score: 0.466
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile (425 Da, Ligand)
- Hiv-1 reverse transcriptase with a dna aptamer in complex with doravirine (Complex from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7z2h
Q-score: 0.384
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit with e138k mutation (Complex from Human immunodeficiency virus type 1 BH10)
- 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile (425 Da, Ligand)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- P51 rt (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Nnrti resistant m184i/e138k mutant hiv-1 reverse transcriptase with a dna aptamer in complex with doravirine (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p66 subunit with m184i mutation (Complex from Human immunodeficiency virus type 1 BH10)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 7ozw
Q-score: 0.448
Singh AK, Martinez SE, Gu W, Nguyen H, Schols D, Herdewijn P, De Jonghe S, Das K
Nat Commun (2021) 12 pp. 7127-7127 [ Pubmed: 34880240 DOI: doi:10.1038/s41467-021-27409-y ]
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase with a dna aptamer in complex with fragment 166 at the transient p-pocket (128 kDa, Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Dna (37-mer) (11 kDa, DNA from synthetic construct)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 group M subtype B (isolate BH10))
- (1~{r},2~{r})-2-phenyl-~{n}-(1,3-thiazol-2-yl)cyclopropane-1-carboxamide (244 Da, Ligand)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7p15
Q-score: 0.433
Singh AK, Martinez SE, Gu W, Nguyen H, Schols D, Herdewijn P, De Jonghe S, Das K
Nat Commun (2021) 12 pp. 7127-7127 [ Pubmed: 34880240 DOI: doi:10.1038/s41467-021-27409-y ]
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- (1~{r},2~{r})-~{n}-(1~{h}-pyrazol-4-yl)-2-pyridin-3-yl-cyclopropane-1-carboxamide (228 Da, Ligand)
- Dna (37-mer) (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Dna (37-mer) (11 kDa, DNA from synthetic construct)
- Cryo-em structure of hiv-1 reverse transcriptase with a dna aptamer in complex with fragment f04 at the transient p-pocket (11 kDa, Complex from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 6ymw
Q-score: 0.41
De Wijngaert B, Sultana S, Singh A, Dharia C, Vanbuel H, Shen J, Vasilchuk D, Martinez SE, Kandiah E, Patel SS, Das K
Mol Cell (2021) 81 pp. 268- [ DOI: doi:10.1016/j.molcel.2020.11.016 Pubmed: 33278362 ]
- Dna (Complex from Saccharomyces cerevisiae)
- Mitochondrial transcription factor 1 (41 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mitochondria dna-dependent rna polymerase pre-initiation complex (202 kDa, Complex)
- Chains: t (10 kDa, DNA from Saccharomyces cerevisiae S288C)
- Mitochondria dna-dependent rna polymerase pre-initiation complex (Complex from Saccharomyces cerevisiae)
- Dna-directed rna polymerase, mitochondrial (143 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- [[(2~{r},3~{s},4~{r},5~{r})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl] phosphono hydrogen phosphate (500 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Rna (pppgpg) (805 Da, RNA from synthetic construct)
- Chains: n (10 kDa, DNA from Saccharomyces cerevisiae S288C)
- Rna (pppgpg) (Complex from synthetic construct)
Cryo-EM structure of yeast mitochondrial RNA polymerase transcription pre-initiation complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6ymv
Q-score: 0.536
De Wijngaert B, Sultana S, Singh A, Dharia C, Vanbuel H, Shen J, Vasilchuk D, Martinez SE, Kandiah E, Patel SS, Das K
Mol Cell (2021) 81 pp. 268- [ DOI: doi:10.1016/j.molcel.2020.11.016 Pubmed: 33278362 ]
- Dna (Complex from Saccharomyces cerevisiae)
- Mitochondrial transcription factor 1 (41 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mitochondria dna-dependent rna polymerase pre-initiation complex (202 kDa, Complex)
- Dna (33-mer) non-template (10 kDa, DNA from Saccharomyces cerevisiae)
- Dna-directed rna polymerase, mitochondrial (143 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (33-mer) template (10 kDa, DNA from Saccharomyces cerevisiae)
- Mitochondria dna-dependent rna polymerase pre-initiation complex (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))