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Liu B, Liu H, Han P, Wang X, Wang C, Yan X, Lei W, Xu K, Zhou J, Qi J, Fan R, Wu G, Tian WX, Gao GF, Wang Q
Signal Transduct Target Ther (2024) 9 pp. 131-131 [ Pubmed: 38740785 DOI: doi:10.1038/s41392-024-01847-8 ]
- Nanobody n235 (13 kDa, Protein from Vicugna pacos)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The n-terminal domain of omicron ba.1 in complex with nanobody n235 and s2l20 fab (Complex from Vicugna pacos)
- Spike protein s2' (34 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 light chain (26 kDa, Protein from Homo sapiens)
- S2l20 heavy chain (52 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8kdb
Q-score: 0.577
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
- Human parainfluenza virus hpiv3 l-p polymerase in dimeric form (Complex from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8j18
Q-score: 0.499
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
- (3r)-3-hydroxydodecanoic acid (216 Da, Ligand)
- 3-oh-c12-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
Cryo-EM Structure of biliverdin-bound mitochondrial ABC transporter ABCB10 from Biortus
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7y48
Q-score: 0.492
Cao S, Yang Y, He L, Hang Y, Yan X, Shi H, Wu J, Ouyang Z
Nat Commun (2023) 14 pp. 2030-2030 [ Pubmed: 37041204 DOI: doi:10.1038/s41467-023-37851-9 ]
- Atp-binding cassette sub-family b member 10, mitochondrial (67 kDa, Protein from Homo sapiens)
- Biliverdine ix alpha (582 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Complex of abcb10 binding with biliverdin (Complex from Homo sapiens)
Cryo-EM structure of SAH-bound MTA1-MTA9-p1-p2 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7yi8
Q-score: 0.499
Yan J, Liu F, Guan Z, Yan X, Jin X, Wang Q, Wang Z, Yan J, Zhang D, Liu Z, Wu S, Yin P
Cell Discov (2023) 9 pp. 8-8 [ DOI: doi:10.1038/s41421-022-00516-w Pubmed: 36658132 ]
- Mta9 (52 kDa, Protein from Tetrahymena thermophila SB210)
- Mt-a70 family protein (42 kDa, Protein from Tetrahymena thermophila SB210)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Mtac holoenzyme (Complex from Tetrahymena thermophila SB210)
- P1 (41 kDa, Protein from Tetrahymena thermophila SB210)
- Transmembrane protein, putative (19 kDa, Protein from Tetrahymena thermophila SB210)
Cryo-EM structure of SAM-bound MTA1-MTA9-p1-p2 complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7yi9
Q-score: 0.522
Yan J, Liu F, Guan Z, Yan X, Jin X, Wang Q, Wang Z, Yan J, Zhang D, Liu Z, Wu S, Yin P
Cell Discov (2023) 9 pp. 8-8 [ DOI: doi:10.1038/s41421-022-00516-w Pubmed: 36658132 ]
- Mta9 (52 kDa, Protein from Tetrahymena thermophila SB210)
- Mt-a70 family protein (42 kDa, Protein from Tetrahymena thermophila SB210)
- Mtac holoenzyme (Complex from Tetrahymena thermophila SB210)
- P1 (41 kDa, Protein from Tetrahymena thermophila SB210)
- Transmembrane protein, putative (19 kDa, Protein from Tetrahymena thermophila SB210)
- S-adenosylmethionine (398 Da, Ligand)
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7ed5
Q-score: 0.522
Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B
Nat Commun (2022) 13 pp. 621-621 [ Pubmed: 35110538 DOI: doi:10.1038/s41467-022-28113-1 ]
- Non-structural protein 8 (24 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(p*gp*cp*up*ap*up*gp*up*gp*ap*gp*ap*up*up*ap*ap*gp*up*up*ap*u*(at9))-3') (6 kDa, RNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Nsp12-nsp7-nsp8 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (12 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(p*cp*cp*cp*cp*ap*up*ap*ap*cp*up*up*ap*ap*up*cp*up*cp*ap*cp*ap*up*ap*gp*c)-3') (9 kDa, RNA from synthetic construct)
- [[(2r,3r,4r,5r)-5-(2-azanyl-6-oxidanylidene-1h-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (539 Da, Ligand)
- Rna (Complex)
- Rna-directed rna polymerase (109 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Nsp12-nsp7-nsp8-rna-at9010 (160 kDa, Complex)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7vdh
Q-score: 0.53
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{n}-methyl-ethanamine (519 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with c48/80, state2 (Complex from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vdm
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- The pseudoallergen receptor mrgprx2 complex with substance p (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Peptide from protachykinin-1 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12. state1
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7vuy
Q-score: 0.509
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ Pubmed: 34789875 DOI: doi:10.1038/s41586-021-04077-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state1 (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)