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Langya henipavirus fusion protein in prefusion state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8tvf
Q-score: 0.59
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Langya henipavirus fusion protein in prefusion state (58 kDa, Protein from Langya virus)
- Langya henipavirus fusion protein in prefusion state (Complex from Langya virus)
- Water (18 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tvg
Q-score: 0.509
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tvh
Q-score: 0.498
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein (58 kDa, Protein from Langya virus)
- 4g5 light chain (11 kDa, Protein from Mus musculus)
- Langya henipavirus postfusion fusion protein in complex with 4g5 fab (Complex from Langya virus)
- 4g5 heavy chain (13 kDa, Protein from Mus musculus)
Langya henipavirus postfusion fusion protein in complex with 4G5 Fab (global refinement)
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- 4g5 fab light chain variable domain (Protein from Mus sp.)
- Langya henipavirus postfusion fusion protein in complex with 4g5 fab (Complex from Langya virus)
- 4g5 fab heavy chain variable domain (Protein from Mus sp.)
- Langya henipavirus fusion protein in postfusion state (Protein from Langya virus)
Ghanaian virus fusion glycoprotein (GhV F)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tvb
Q-score: 0.56
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- Prefusion ghanian henipavirus f fused to the i53-50a trimer via an intervening 16 gs linker (Complex from Henipavirus ghanaense)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (96 kDa, Protein from Thermotoga maritima MSB8)
Langya Virus G glycoprotein (LayV G) with stabilizing mutations
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tvi
Q-score: 0.552
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- Stabilized langya virus attachment glycoprotein layvg (Complex from Langya virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Langya virus attachment glycoprotein g (68 kDa, Protein from Langya virus)
Langya Virus attachment (G) glycoprotein with K85L/L86K mutation
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8vwp
Q-score: 0.543
Wang Z, McCallum M, Yan L, Gibson CA, Sharkey W, Park YJ, Dang HV, Amaya M, Person A, Broder CC, Veesler D
PNAS (2024) 121 pp. e2314990121-e2314990121 [ DOI: doi:10.1073/pnas.2314990121 Pubmed: 38593070 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Langya virus attachment (g) protein (Complex from Langya virus)
- Langya virus attachment (g) protein (59 kDa, Protein from Langya virus)
Cryo-EM structure of the yeast TOM core complex crosslinked by BS3 (from TOM-TIM23 complex)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8w5k
Q-score: 0.436
Wang Q, Zhuang J, Huang R, Guan Z, Yan L, Hong S, Zhang L, Huang C, Liu Z, Yin P
Cell Discov (2024) 10 pp. 19-19 [ Pubmed: 38360717 DOI: doi:10.1038/s41421-023-00643-y ]
- Mitochondrial import receptor subunit tom6 (6 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mitochondrial import receptor subunit tom22 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- (2r)-3-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate (635 Da, Ligand)
- Mitochondrial import receptor subunit tom5 (5 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mitochondrial import receptor subunit tom7 (6 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Tom-tim23 complex (Complex from Saccharomyces cerevisiae S288C)
- Mitochondrial import receptor subunit tom40 (42 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8gwk
Q-score: 0.423
Yan L, Huang Y, Ge J, Liu Z, Lu P, Huang B, Gao S, Wang J, Tan L, Ye S, Yu F, Lan W, Xu S, Zhou F, Shi L, Guddat LW, Gao Y, Rao Z, Lou Z
Cell (2022) 185 pp. 4347-4360.e17 [ DOI: doi:10.1016/j.cell.2022.09.037 Pubmed: 36335936 ]
- [(2~{r},3~{s},4~{r},5~{r})-5-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate (371 Da, Ligand)
- Water (18 Da, Ligand)
- Non-structural protein 9 (12 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Primer (8 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Magnesium ion (24 Da, Ligand)
- Rna-directed rna polymerase (106 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- E-rtc_rmp-nsp9_gmppnp (Complex from Severe acute respiratory syndrome coronavirus 2)
- Template (8 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Helicase (66 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)