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Cryo-EM structure of the amthamine-bound H2R-Gs complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yut
Q-score: 0.529
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Histamine h2 receptor (46 kDa, Protein from Homo sapiens)
- Amthamine-bound h2r-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine (157 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of the histamine-bound H3R-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yuu
Q-score: 0.566
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of the immepip-bound H3R-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8yuv
Q-score: 0.532
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Cholesterol hemisuccinate (486 Da, Ligand)
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hlp
Q-score: 0.435
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hma
Q-score: 0.424
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav1.2alpha2delta1beta2b (Complex from Homo sapiens)
- 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman (620 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8hmb
Q-score: 0.472
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- (3r)-1-benzylpiperidin-3-yl methyl (2r,3r,4r,5r,6s)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate (506 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xzg
Q-score: 0.495
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Cryo-em structure of the [pyr1]-apelin-13-bound human aplnr-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzf
Q-score: 0.578
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Cryo-em structure of the wn561-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Wn561 (1 kDa, Protein from synthetic construct)