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Cryo-EM structure of IRL1620-bound ETBR-Gi complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8hbd
Q-score: 0.412
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Endothelin receptor type b,endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Irl1620-bound etbr-gi complex (Complex from Homo sapiens)
- Irl1620 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
Cryo-EM structure of endothelin1-bound ETAR-Gq complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hcq
Q-score: 0.394
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Endothelin-1 receptor,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (69 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
- Scfv16 (30 kDa, Protein from Mus musculus)
Cryo-EM structure of Endothelin1-bound ETBR-Gq complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hcx
Q-score: 0.346
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
- Scfv16 (30 kDa, Protein from Mus musculus)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ DOI: doi:10.1038/s41421-022-00499-8 Pubmed: 36543774 ]
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gy7
Q-score: 0.453
Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y
Cell Res (2023) 33 pp. 46-54 [ DOI: doi:10.1038/s41422-022-00751-6 Pubmed: 36588120 ]
- Corticotropin (2 kDa, Protein from synthetic construct)
- Acth (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Melanocortin-2 receptor (Complex from Homo sapiens)
- Acth-bound melanocortin-2 receptor in complex with mrap1 and gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
- Mrap1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Soluble cytochrome b562,adrenocorticotropic hormone receptor,melanocortin-2 receptor,adrenocorticotropic hormone receptor,adrenocorticotropic hormone receptor (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Melanocortin-2 receptor accessory protein (20 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w53
Q-score: 0.514
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ DOI: doi:10.1038/s41467-022-29683-w Pubmed: 35440625 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Neuromedin-u-25 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 1 (83 kDa, Protein from Homo sapiens)
- The neuromedin u-bound neuromedin u receptor 1-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7w55
Q-score: 0.489
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ DOI: doi:10.1038/s41467-022-29683-w Pubmed: 35440625 ]
- Neuromedin-u-25 (3 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 2 (65 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- The neuromedin u-bound neuromedin u receptor 2-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7w56
Q-score: 0.477
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ DOI: doi:10.1038/s41467-022-29683-w Pubmed: 35440625 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Neuromedin u receptor 1 (83 kDa, Protein from Homo sapiens)
- Neuromedin-s (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- The neuromedin s-bound neuromedin u receptor 1-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w57
Q-score: 0.533
You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y
Nat Commun (2022) 13 pp. 2045-2045 [ DOI: doi:10.1038/s41467-022-29683-w Pubmed: 35440625 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Neuromedin-u receptor 2 (65 kDa, Protein from Homo sapiens)
- The neuromedin s-bound neuromedin u receptor 2-gq protein complex (Complex from Homo sapiens)
- Neuromedin-s (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7cz5
Q-score: 0.582
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2020) 11 pp. 5205-5205 [ DOI: doi:10.1038/s41467-020-18945-0 Pubmed: 33060564 ]
- Palmitic acid (256 Da, Ligand)
- Growth hormone-releasing hormone receptor - gs protein complex (180 kDa, Complex)
- Somatoliberin (5 kDa, Protein from Homo sapiens)
- Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor (61 kDa, Protein from Homo sapiens)
- Nanobody35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody35 (13 kDa, Protein from synthetic construct)
- G(s) subunit beta-1 (Complex from Rattus norvegicus)
- Hormone (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Water (18 Da, Ligand)
- G(s) subunit gamma-2 (Complex from Bos taurus)
- Hormone receptor, g(s) subunit alpha isoforms (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)