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Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8iuk
Q-score: 0.45
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ DOI: doi:10.1038/s41467-023-38411-x Pubmed: 37160891 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pgf2-alpha-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8iul
Q-score: 0.484
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ DOI: doi:10.1038/s41467-023-38411-x Pubmed: 37160891 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the latanoprost-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8ium
Q-score: 0.433
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ DOI: doi:10.1038/s41467-023-38411-x Pubmed: 37160891 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (~{z})-7-[(1~{r},2~{r},3~{r},5~{s})-2-[(~{e})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid (410 Da, Ligand)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Cryo-em structure of the tafluprost acid-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of IRL1620-bound ETBR-Gi complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8hbd
Q-score: 0.412
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Irl1620 (1 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Irl1620-bound etbr-gi complex (Complex from Homo sapiens)
- Endothelin receptor type b,endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
Cryo-EM structure of endothelin1-bound ETAR-Gq complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hcq
Q-score: 0.394
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Endothelin-1 receptor,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
- Scfv16 (30 kDa, Protein from Mus musculus)
Cryo-EM structure of Endothelin1-bound ETBR-Gq complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hcx
Q-score: 0.346
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ Pubmed: 36882417 DOI: doi:10.1038/s41467-023-36998-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-1 (28 kDa, Protein from Homo sapiens)
- Endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Et1-etar-gq-scfv16 complex (Complex from Homo)
- Scfv16 (30 kDa, Protein from Mus musculus)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ Pubmed: 36543774 DOI: doi:10.1038/s41421-022-00499-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
Galanin-bound galanin receptor 1 in complex with Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7wq3
Q-score: 0.312
Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y
Nat Commun (2022) 13 pp. 1364- [ DOI: doi:10.1038/s41467-022-29072-3 ]
- Galanin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Galanin receptor type 1 (38 kDa, Protein from Homo sapiens)
- Galanin-gal1r-gi-scfv16 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Galanin (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Rattus)
- Galanin receptor type 1 (Complex from Homo sapiens)
Galanin-bound galanin receptor 2 in complex with Gq
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7wq4
Q-score: 0.528
Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y
Nat Commun (2022) 13 pp. 1364- [ DOI: doi:10.1038/s41467-022-29072-3 ]
- Galanin receptor type 2 (Complex)
- Galanin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (Complex from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- Nb35 (14 kDa, Protein from Lama glama)
- Galanin-gal2r-gq-nb35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus)
- Nb35 (Complex from Bos taurus)
- Galanin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Galanin (Complex from Homo sapiens)