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Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gy7
Q-score: 0.453
Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y
Cell Res (2023) 33 pp. 46-54 [ Pubmed: 36588120 DOI: doi:10.1038/s41422-022-00751-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Acth-bound melanocortin-2 receptor in complex with mrap1 and gs protein (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Melanocortin-2 receptor (Complex from Homo sapiens)
- Soluble cytochrome b562,adrenocorticotropic hormone receptor,melanocortin-2 receptor,adrenocorticotropic hormone receptor,adrenocorticotropic hormone receptor (67 kDa, Protein from Homo sapiens)
- Acth (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Mrap1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Corticotropin (2 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Melanocortin-2 receptor accessory protein (20 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dur
Q-score: 0.273
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Nanobody-35 (Complex from synthetic construct)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7evm
Q-score: 0.481
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Guanine nucleotide-binding (Complex from Homo sapiens)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Glp-1 receptor (Complex from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7duq
Q-score: 0.536
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Cryo-em structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex (Complex)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 (3 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Glucagon-like peptide 1 (Complex from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor
Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7cz5
Q-score: 0.582
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2020) 11 pp. 5205-5205 [ Pubmed: 33060564 DOI: doi:10.1038/s41467-020-18945-0 ]
- G(s) subunit beta-1 (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Nanobody35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- G(s) subunit gamma-2 (Complex from Bos taurus)
- Palmitic acid (256 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Hormone receptor, g(s) subunit alpha isoforms (Complex from Homo sapiens)
- Hormone (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Growth hormone-releasing hormone receptor - gs protein complex (180 kDa, Complex)
- Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor (61 kDa, Protein from Homo sapiens)
- Somatoliberin (5 kDa, Protein from Homo sapiens)