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Cryo-EM structure of adenosine receptor A3AR bound to CF101
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8x16
Q-score: 0.31
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE
Nat Commun (2024) 15 pp. 3252-3252 [ Pubmed: 38627384 DOI: doi:10.1038/s41467-024-47207-6 ]
- Scfv16 (Complex from Mus musculus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Piclidenoson (510 Da, Ligand)
- A3ar (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
- Cryo-em structure of adenosine receptor a3ar bound to cf101 (160 kDa, Complex)
- G protein (Complex from Bos taurus)
- Adenosine receptor a3 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G protein (Complex from Rattus norvegicus)
Cryo-EM structure of adenosine receptor A3AR bound to CF102
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8x17
Q-score: 0.473
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE
Nat Commun (2024) 15 pp. 3252-3252 [ Pubmed: 38627384 DOI: doi:10.1038/s41467-024-47207-6 ]
- Cryo-em structure of adenosine receptor a3ar bound to cf102 (160 kDa, Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Namodenoson (544 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
- G protein (Complex from Bos taurus)
- Adenosine receptor a3 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- A3ar (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from Mus musculus)
- G protein (Complex from Homo sapiens)
Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8j18
Q-score: 0.499
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- 3-oh-c12-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- (3r)-3-hydroxydodecanoic acid (216 Da, Ligand)
Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8j19
Q-score: 0.49
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- Ly237-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 6-nonylpyridine-2,4-diol (237 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8j1a
Q-score: 0.484
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Gpr84 receptor-gi complex with no ligand modeled (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Structure of A2BR bound to synthetic agonists BAY 60-6583
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8hdo
Q-score: 0.497
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ DOI: doi:10.1038/s41421-022-00503-1 Pubmed: 36575181 ]
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- A2br-g protein-bay 60-6583 complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide (379 Da, Ligand)
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- Cholesterol (386 Da, Ligand)
Structure of A2BR bound to endogenous agonists adenosine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hdp
Q-score: 0.428
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ DOI: doi:10.1038/s41421-022-00503-1 Pubmed: 36575181 ]
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- A2br-g protein-adenosine complex (160 kDa, Complex from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- Cholesterol (386 Da, Ligand)
- Adenosine (267 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xz5
Q-score: 0.514
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Nb35 (Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Gpr119-gs (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr119-gs-nb35-lpc complex (Complex from Homo sapiens)
- (4r,7r,18e)-4,7-dihydroxy-n,n,n-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide (522 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xz6
Q-score: 0.552
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Gpr119-gs (Complex from Lama glama)
- Nb35 (Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpr119-gs-nb35-apd668 complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate (477 Da, Ligand)
ghrelin-bound ghrelin receptor in complex with Gq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f9y
Q-score: 0.469
Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y
Nat Commun (2021) 12 pp. 5064-5064 [ Pubmed: 34417468 DOI: doi:10.1038/s41467-021-25364-2 ]
- Engineered g-alpha-q subunit (41 kDa, Protein from Homo sapiens)
- Ghrelin-bound ghrelin receptor in complex with gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562 (74 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ghrelin-28 (3 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Octanoic acid (caprylic acid) (144 Da, Ligand)