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VMAT1 dimer with MPP+ and reserpine
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tgg
Q-score: 0.371
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Complex of vmat1 with mpp+ and reserpine (105 kDa, Complex from Homo sapiens)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
- 1-methyl-4-phenylpyridin-1-ium (170 Da, Ligand)
VMAT1 dimer with amphetamine and reserpine
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tgh
Q-score: 0.479
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
- Complex of vmat1 with amphetamine and reserpine (105 kDa, Complex from Homo sapiens)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
VMAT1 dimer with dopamine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgi
Q-score: 0.396
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
- Complex of vmat1 dimer with dopamine and reserpine (105 kDa, Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
VMAT1 dimer with histamine and reserpine
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8tgk
Q-score: 0.42
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Complex of vmat1 dimer with histamine and reserpine (105 kDa, Complex from Homo sapiens)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
- Histamine (111 Da, Ligand)
VMAT1 dimer with norepinephrine and reserpine
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8tgl
Q-score: 0.413
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Complex of vmat1 with norepinephrine and reserpine (105 kDa, Complex from Homo sapiens)
- L-norepinephrine (169 Da, Ligand)
- Chromaffin granule amine transporter (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tgm
Q-score: 0.457
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024) 629 pp. 235-243 [ DOI: doi:10.1038/s41586-024-07290-7 Pubmed: 38499039 ]
- Vmat1 dimer with reserpine (105 kDa, Complex from Homo sapiens)
- Vmat1 dimer with reserpine (50 kDa, Protein from Homo sapiens)
- Reserpine (608 Da, Ligand)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8dtk
Q-score: 0.437
Malewana RD, Stalls V, May A, Lu X, Martinez DR, Schafer A, Li D, Barr M, Sutherland LL, Lee E, Parks R, Beck WE, Newman A, Bock KW, Minai M, Nagata BM, DeMarco CT, Denny TN, Oguin 3rd TH, Rountree W, Wang Y, Mansouri K, Edwards RJ, Sempowski GD, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain DW, Santra S, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Montefiori DC, Pardi N, Weissman D, Baric RS, Acharya P, Haynes BF, Saunders KO
bioRxiv (2023) [ Pubmed: 38187726 DOI: doi:10.1101/2023.12.18.572191 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rbd directed antibody dh1047 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Dh1047 fab light chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh1047 fab heavy chain (14 kDa, Protein from Homo sapiens)
Native alpha-2-macroglobulin monomer
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 7von
Q-score: 0.321
Huang X, Wang Y, Yu C, Zhang H, Ru Q, Li X, Song K, Zhou M, Zhu P
Sci China Life Sci (2022) 65 pp. 2491-2504 [ DOI: doi:10.1007/s11427-022-2139-2 Pubmed: 35781771 ]
- Alpha-2-macroglobulin (160 kDa, Protein from Homo sapiens)
- Native alpha-2-macroglobulin (Tissue from Homo sapiens)
Induced alpha-2-macroglobulin monomer
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7voo
Q-score: 0.314
Huang X, Wang Y, Yu C, Zhang H, Ru Q, Li X, Song K, Zhou M, Zhu P
Sci China Life Sci (2022) 65 pp. 2491-2504 [ DOI: doi:10.1007/s11427-022-2139-2 Pubmed: 35781771 ]
- Macroglobulin family protein (Tissue from Homo sapiens)
- Alpha-2-macroglobulin (145 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
