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Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hlp
Q-score: 0.435
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hma
Q-score: 0.424
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav1.2alpha2delta1beta2b (Complex from Homo sapiens)
- 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman (620 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8hmb
Q-score: 0.472
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ DOI: doi:10.1038/s41467-024-47116-8 Pubmed: 38555290 ]
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- (3r)-1-benzylpiperidin-3-yl methyl (2r,3r,4r,5r,6s)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate (506 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of Arabidopsis thaliana SOS1 in an occluded state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7y3e
Q-score: 0.539
Wang Y, Pan C, Chen Q, Xie Q, Gao Y, He L, Li Y, Dong Y, Jiang X, Zhao Y
Nat Commun (2023) 14 pp. 4487-4487 [ Pubmed: 37495621 DOI: doi:10.1038/s41467-023-40215-y ]
- Sodium/hydrogen exchanger 7 (127 kDa, Protein from Arabidopsis thaliana)
- Arabidopsis sodium/hydrogen exchanger 7 (sos1), homodimer (Complex from Arabidopsis thaliana)
- Hexadecane (226 Da, Ligand)
Cryo-EM structure of Arabidopsis thaliana SOS1 in an occluded state, with expanded TMD
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hya
Q-score: 0.429
Wang Y, Pan C, Chen Q, Xie Q, Gao Y, He L, Li Y, Dong Y, Jiang X, Zhao Y
Nat Commun (2023) 14 pp. 4487-4487 [ Pubmed: 37495621 DOI: doi:10.1038/s41467-023-40215-y ]
- Sodium/hydrogen exchanger 7 (127 kDa, Protein from Arabidopsis thaliana)
- Arabidopsis sodium/hydrogen exchanger 7 (sos1), expand (Complex from Arabidopsis thaliana)
- Hexadecane (226 Da, Ligand)
CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wli
Q-score: 0.443
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
Nat Commun (2022) 13 pp. 2084-2084 [ DOI: doi:10.1038/s41467-022-29728-0 Pubmed: 35440630 ]
- Voltage-dependent t-type calcium channel subunit alpha-1i (245 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cav3.3 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7wlj
Q-score: 0.366
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
Nat Commun (2022) 13 pp. 2084-2084 [ DOI: doi:10.1038/s41467-022-29728-0 Pubmed: 35440630 ]
- (1s,2s)-2-(2-{[3-(1h-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate (495 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1i (245 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cav3.3 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7wlk
Q-score: 0.438
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
Nat Commun (2022) 13 pp. 2084-2084 [ DOI: doi:10.1038/s41467-022-29728-0 Pubmed: 35440630 ]
- Voltage-dependent t-type calcium channel subunit alpha-1i (245 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cav3.3 (Complex from Homo sapiens)
- 2-[diethyl(methyl)-$l^{4}-azanyl]ethyl 4-[(2-octoxyphenyl)carbonylamino]benzoate (483 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7wll
Q-score: 0.425
He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y
Nat Commun (2022) 13 pp. 2084-2084 [ DOI: doi:10.1038/s41467-022-29728-0 Pubmed: 35440630 ]
- Voltage-dependent t-type calcium channel subunit alpha-1i (245 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Cav3.3 (Complex from Homo sapiens)
- 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{h}-benzimidazol-2-one (461 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vfs
Q-score: 0.533
Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y
Cell Rep (2021) 37 pp. 109931-109931 [ DOI: doi:10.1016/j.celrep.2021.109931 Pubmed: 34731621 ]
- Cav2.2-alpha2delta1-beta1 complex (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Voltage-dependent n-type calcium channel subunit alpha-1b (262 kDa, Protein from Homo sapiens)