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Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution
Resolution: 2.32 Å
EM Method: Single-particle
Fitted PDBs: 7sq6
Q-score: 0.659
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- 2-{2-oxo-2-[(4s)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2h)-yl]ethyl}-1h-isoindole-1,3(2h)-dione (362 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 7sq7
Q-score: 0.627
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Water (18 Da, Ligand)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution
Resolution: 2.598 Å
EM Method: Single-particle
Fitted PDBs: 7sq8
Q-score: 0.618
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Water (18 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 7sq9
Q-score: 0.69
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- (1r,2r,4s)-4-{(2r)-2-[(3s,6r,7e,9r,10r,12r,14s,15e,17e,19e,21s,23s,26r,27r,30s,34as)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3h-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate (1 kDa, Ligand)
- Sodium ion (22 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Water (18 Da, Ligand)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7lft
Q-score: 0.638
Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Neuron (2021) 109 pp. 1302-1313.e4 [ Pubmed: 33651975 DOI: doi:10.1016/j.neuron.2021.02.007 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Apo cnga1 homotetramer in k+/ca2+ (Cell from Homo sapiens)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of human cGMP-bound open CNGA1 channel in K+/Ca2+
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7lfw
Q-score: 0.551
Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Neuron (2021) 109 pp. 1302-1313.e4 [ Pubmed: 33651975 DOI: doi:10.1016/j.neuron.2021.02.007 ]
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cgmp-bound open cnga1 homotetramer in k+/ca2+ (Cell from Homo sapiens)
Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7lfx
Q-score: 0.458
Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Neuron (2021) 109 pp. 1302-1313.e4 [ Pubmed: 33651975 DOI: doi:10.1016/j.neuron.2021.02.007 ]
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cgmp-bound open cnga1 homotetramer in na+/ca2+ (Cell from Homo sapiens)
Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7lfy
Q-score: 0.416
Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Neuron (2021) 109 pp. 1302-1313.e4 [ Pubmed: 33651975 DOI: doi:10.1016/j.neuron.2021.02.007 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cgmp-bound open cnga1 homotetramer in na+ (Cell from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7lg1
Q-score: 0.527
Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Neuron (2021) 109 pp. 1302-1313.e4 [ Pubmed: 33651975 DOI: doi:10.1016/j.neuron.2021.02.007 ]
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cgmp-bound cnga1_e365q homotetramer in na+/ca2+ (Cell from Homo sapiens)
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)