The structure of EBOV L-VP35-RNA complex
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8jsl
Q-score: 0.547
Peng Q, Yuan B, Cheng J, Wang M, Gao S, Bai S, Zhao X, Qi J, Gao GF, Shi Y
Nature (2023) 622 pp. 603-610 [ Pubmed: 37699521 DOI: doi:10.1038/s41586-023-06608-1 ]
- The leader sequence of ebov (5 kDa, RNA from Ebola virus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
- The structure of ebov l-vp35-rna complex (Complex from Ebola virus)
The structure of EBOV L-VP35-RNA complex (conformation 1)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jsm
Q-score: 0.495
Peng Q, Yuan B, Cheng J, Wang M, Gao S, Bai S, Zhao X, Qi J, Gao GF, Shi Y
Nature (2023) 622 pp. 603-610 [ Pubmed: 37699521 DOI: doi:10.1038/s41586-023-06608-1 ]
- The leader sequence of ebov genome. (5 kDa, RNA from Ebola virus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
- The structure of ebov l-vp35-rna complex (conformation 1) (Complex from Ebola virus)
The structure of EBOV L-VP35-RNA complex (conformation 2)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jsn
Q-score: 0.475
Peng Q, Yuan B, Cheng J, Wang M, Gao S, Bai S, Zhao X, Qi J, Gao GF, Shi Y
Nature (2023) 622 pp. 603-610 [ Pubmed: 37699521 DOI: doi:10.1038/s41586-023-06608-1 ]
- The leader sequence of ebov genome (5 kDa, RNA from Ebola virus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- The structure of ebov l-vp35-rna complex (conformation 2) (Complex from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
The structure of EBOV L-VP35 complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7yer
Q-score: 0.531
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature (2022) 610 pp. 394-401 [ Pubmed: 36171293 DOI: doi:10.1038/s41586-022-05271-2 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- The complex of ebov l-vp35 (Complex from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
The structure of EBOV L-VP35-RNA complex (state2)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yes
Q-score: 0.49
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature (2022) 610 pp. 394-401 [ Pubmed: 36171293 DOI: doi:10.1038/s41586-022-05271-2 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- The complex of ebov l-vp35 (Complex from Ebola virus)
- Vp35 of ebov l-vp35 complex (37 kDa, Protein from Ebola virus)
The structure of EBOV L-VP35 in complex with suramin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7yet
Q-score: 0.45
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature (2022) 610 pp. 394-401 [ Pubmed: 36171293 DOI: doi:10.1038/s41586-022-05271-2 ]
- The complex of ebov l-vp35-suramin (Complex from Ebola virus)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfon ic acid (1 kDa, Ligand)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7el9
Q-score: 0.415
Xu X, Peng R, Peng Q, Wang M, Xu Y, Liu S, Tian X, Deng H, Tong Y, Hu X, Zhong J, Wang P, Qi J, Gao GF, Shi Y
Nat Microbiol (2021) 6 pp. 921-931 [ Pubmed: 34127846 DOI: doi:10.1038/s41564-021-00916-w ]
- Machupo virus 3'-vrna promoter (Complex from Machupo mammarenavirus)
- Machupo virus polymerase in complex with z martix protein and 3'-vrna in dimeric form. (580 kDa, Complex from Machupo mammarenavirus)
- Machupo virus 3'-vrna promoter (6 kDa, RNA from Machupo mammarenavirus)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Machupo virus z matrix protein (Complex)
- Rna-directed rna polymerase l (250 kDa, Protein from Machupo mammarenavirus)
- Ring finger protein z (10 kDa, Protein from Machupo mammarenavirus)
- Machupo virus polymerase (Complex)
Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ela
Q-score: 0.447
Xu X, Peng R, Peng Q, Wang M, Xu Y, Liu S, Tian X, Deng H, Tong Y, Hu X, Zhong J, Wang P, Qi J, Gao GF, Shi Y
Nat Microbiol (2021) 6 pp. 921-931 [ Pubmed: 34127846 DOI: doi:10.1038/s41564-021-00916-w ]
- Rna-directed rna polymerase l (253 kDa, Protein from Lassa mammarenavirus)
- Lassa virus z protein (Complex)
- Manganese (ii) ion (54 Da, Ligand)
- 3-'vrna promoter (Complex from Lassa mammarenavirus)
- Zinc ion (65 Da, Ligand)
- Lassa virus polymerase in complex with 3'-vrna and z mutant (f36a). (270 kDa, Complex from Lassa mammarenavirus)
- Lassa virus polymerase (Complex)
- Ring finger protein z (10 kDa, Protein from Lassa mammarenavirus)
- 3-'vrna promoter (6 kDa, RNA from Lassa mammarenavirus)
Structure of Machupo virus L polymerase in complex with Z protein (dimeric form)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7elb
Q-score: 0.229
Xu X, Peng R, Peng Q, Wang M, Xu Y, Liu S, Tian X, Deng H, Tong Y, Hu X, Zhong J, Wang P, Qi J, Gao GF, Shi Y
Nat Microbiol (2021) 6 pp. 921-931 [ Pubmed: 34127846 DOI: doi:10.1038/s41564-021-00916-w ]
- Machupo virus polymerase (Complex from Machupo mammarenavirus)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Machupo virus z matrix protein (Complex)
- Machupo virus polymerase in complex with z protein (dimeric form). (580 kDa, Complex from Machupo mammarenavirus)
- Rna-directed rna polymerase l (250 kDa, Protein from Machupo mammarenavirus)
- Ring finger protein z (10 kDa, Protein from Machupo mammarenavirus)
Structure of monomeric complex of MACV L bound to Z and 3'-vRNA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7elc
Q-score: 0.501
Xu X, Peng R, Peng Q, Wang M, Xu Y, Liu S, Tian X, Deng H, Tong Y, Hu X, Zhong J, Wang P, Qi J, Gao GF, Shi Y
Nat Microbiol (2021) 6 pp. 921-931 [ Pubmed: 34127846 DOI: doi:10.1038/s41564-021-00916-w ]
- Machupo virus z martix protein (Complex)
- 3'-vrna promoter (Complex)
- Machupo virus polymerase in complex with z matrix protein and 3'-vrna in monomeric form (270 kDa, Complex from Machupo mammarenavirus)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (250 kDa, Protein from Machupo mammarenavirus)
- Ring finger protein z (10 kDa, Protein from Machupo mammarenavirus)
- 3'-vrna promoter (6 kDa, RNA from Machupo mammarenavirus)
- Machupo virus polymerse (Complex from Machupo mammarenavirus)