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Structure of a class A GPCR/agonist complex (focused map2)
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
Structure of a class A GPCR/agonist complex (focused map1)
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
Structure of a class A GPCR/agonist complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8u1u
Q-score: 0.515
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ccr8 in complex with ccl1 and gi (Complex from Homo sapiens)
- C-c motif chemokine 1,c-c chemokine receptor type 8,egfp fusion protein (83 kDa, Protein from Human adenovirus C serotype 2)
- Scfv fragment (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Structure of a class A GPCR/agonist complex (Consensus map)
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
COVOX-222 fab in complex with SARS-CoV-2 beta-Spike glycoprotein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7q9g
Q-score: 0.341
Liu C, Zhou D, Nutalai R, Duyvesteyn HME, Tuekprakhon A, Ginn HM, Dejnirattisai W, Supasa P, Mentzer AJ, Wang B, Case JB, Zhao Y, Skelly DT, Chen RE, Johnson SA, Ritter TG, Mason C, Malik T, Temperton N, Paterson NG, Williams MA, Hall DR, Clare DK, Howe A, Goulder PJR, Fry EE, Diamond MS, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR
Cell Host Microbe (2022) 30 pp. 53- [ Pubmed: 34921776 DOI: doi:10.1016/j.chom.2021.11.013 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Covox-222 heavy chain (12 kDa, Protein from Homo sapiens)
- Covox-222 light chain (11 kDa, Protein from Homo sapiens)
- Covox-222 fab in complex with sars-cov-2 beta-spike glycoprotein (475 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Beta-44 fab in complex with SARS-CoV-2 beta-Spike glycoprotein
Liu C, Zhou D, Nutalai R, Duyvesteyn HME, Tuekprakhon A, Ginn HM, Dejnirattisai W, Supasa P, Mentzer AJ, Wang B, Case JB, Zhao Y, Skelly DT, Chen RE, Johnson SA, Ritter TG, Mason C, Malik T, Temperton N, Paterson NG, Williams MA, Hall DR, Clare DK, Howe A, Goulder PJR, Fry EE, Diamond MS, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR
Cell Host Microbe (2022) 30 pp. 53-68.e12 [ Pubmed: 34921776 DOI: doi:10.1016/j.chom.2021.11.013 ]
- Beta-44 fab in complex with sars-cov-2 beta-spike glycoprotein (475 kDa, Complex)
- Sars-cov-2 spike glycoprotein ectodomain, beta variant (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab (Complex from Homo sapiens)
- Beta-44 fab heavy chain (Macromolecule from Homo sapiens)
- Beta-44 fab light chain (Macromolecule from Homo sapiens)
- Sars-cov-2 spike glycoprotein ectodomain, beta variant (Macromolecule from Severe acute respiratory syndrome coronavirus 2)