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Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 7t6x
Q-score: 0.381
Torrents de la Pena A, Sliepen K, Eshun-Wilson L, Newby ML, Allen JD, Zon I, Koekkoek S, Chumbe A, Crispin M, Schinkel J, Lander GC, Sanders RW, Ward AB
Science (2022) 378 pp. 263-269 [ Pubmed: 36264808 DOI: doi:10.1126/science.abn9884 ]
- Ar4a fab, heavy chain (29 kDa, Protein from Homo sapiens)
- Cryoem structure of full-length hepatitis c virus e1e2 glycoprotein in complex with ar4a, at12009 and igh505 fabs (Complex from Hepacivirus C)
- Igh505, lambda light chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein e2 (40 kDa, Protein from Hepacivirus C)
- Igh505, heavy chain (52 kDa, Protein from Homo sapiens)
- At12009 crossmab, light kappa chain (24 kDa, Protein from Homo sapiens)
- At12009 crossmab, heavy chain (29 kDa, Protein from Homo sapiens)
- Ar4a, kappa light chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein e1 (20 kDa, Protein from Hepacivirus C)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 7zlk
Q-score: 0.362
van Schooten J, Schorcht A, Farokhi E, Umotoy JC, Gao H, van den Kerkhof TLGM, Dorning J, Rijkhold Meesters TG, van der Woude P, Burger JA, Bijl T, Ghalaiyini R, Torrents de la Pena A, Turner HL, Labranche CC, Stanfield RL, Sok D, Schuitemaker H, Montefiori DC, Burton DR, Ozorowski G, Seaman MS, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2022) 18 pp. e1010945-e1010945 [ Pubmed: 36395347 DOI: doi:10.1371/journal.ppat.1010945 ]
- Amc009 sosipv5.2 in complex with fabs acs114 and acs122 (17 MDa, Complex from Human immunodeficiency virus 1)
- Acs114 light chain (12 kDa, Protein from Homo sapiens)
- Acs122 heavy chain (13 kDa, Protein from Homo sapiens)
- Acs122 light chain (11 kDa, Protein from Homo sapiens)
- Amc009 sosipv5.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc009 sosipv5.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Acs114 heavy chain (13 kDa, Protein from Homo sapiens)
Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7scn
Q-score: 0.534
Sangesland M, Torrents de la Pena A, Boyoglu-Barnum S, Ronsard L, Mohamed FAN, Moreno TB, Barnes RM, Rohrer D, Lonberg N, Ghebremichael M, Kanekiyo M, Ward A, Lingwood D
Immunity (2022) 55 pp. 1693-1709.e8 [ Pubmed: 35952670 DOI: doi:10.1016/j.immuni.2022.07.006 ]
- Structure of h1 nc99 influenza hemagglutinin bound to 310-63e6 fab (Complex from Influenza A virus)
- 310-63e6 fab, light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (35 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- 310-63e6 fab, heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hemagglutinin ha2 chain (26 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
Structure of H1 influenza hemagglutinin bound to Fab 310-39G10
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7sco
Q-score: 0.451
Sangesland M, Torrents de la Pena A, Boyoglu-Barnum S, Ronsard L, Mohamed FAN, Moreno TB, Barnes RM, Rohrer D, Lonberg N, Ghebremichael M, Kanekiyo M, Ward A, Lingwood D
Immunity (2022) 55 pp. 1693-1709.e8 [ Pubmed: 35952670 DOI: doi:10.1016/j.immuni.2022.07.006 ]
- Hemagglutinin ha1 chain (35 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- 310-39g10 fab, heavy chain (12 kDa, Protein from Homo sapiens)
- 310-39g10 fab, light chain (11 kDa, Protein from Homo sapiens)
- Structure of h1 nc99 influenza hemagglutinin bound to fab 310-39g10 (Complex from Influenza A virus)
- Hemagglutinin ha2 chain (26 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
AMC009 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vo3
Q-score: 0.29
Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, Torrents de la Pena A, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW
J Virol (2020) 94 [ DOI: doi:10.1128/JVI.01214-20 Pubmed: 32999024 ]
- Amc009 sosip.v4.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 light chain (23 kDa, Protein from Homo sapiens)
- Amc009 sosip.v4.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 fab (Complex from Homo sapiens)
- Amc009 sosip.v4.2 in complex with pgv04 fab (Complex)
- Amc009 sosip.v4.2 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgv04 heavy chain (24 kDa, Protein from Homo sapiens)
PGT145 Fab in complex with full length AMC011 HIV-1 Env
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 6nij
Q-score: 0.18
Torrents de la Pena A, Rantalainen K, Cottrell CA, Allen JD, van Gils MJ, Torres JL, Crispin M, Sanders RW, Ward AB
PLoS Pathog (2019) 15 pp. e1007920-e1007920 [ Pubmed: 31306470 DOI: doi:10.1371/journal.ppat.1007920 ]
- Amc011 glycoprotein 120 (Complex from Homo sapiens)
- Amc011 glycoprotein 41 (39 kDa, Protein from Human immunodeficiency virus 1)
- Pgt145 fab light chain (12 kDa, Protein from Homo sapiens)
- Pgt145 (Complex from Homo sapiens)
- Amc011 glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Pgt145 fab in complex with full length amc011 hiv-1 env (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt145 fab heavy chain (15 kDa, Protein from Homo sapiens)
- Amc011 glycoprotein 41 (Complex from Homo sapiens)
Full length HIV-1 Env AMC011 in complex with PGT151 Fab
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6olp
Q-score: 0.399
Torrents de la Pena A, Rantalainen K, Cottrell CA, Allen JD, van Gils MJ, Torres JL, Crispin M, Sanders RW, Ward AB
PLoS Pathog (2019) 15 pp. e1007920-e1007920 [ Pubmed: 31306470 DOI: doi:10.1371/journal.ppat.1007920 ]
- Pgt151 fab in complex with full length amc011 hiv-1 env (Complex)
- Envelope glycoprotein gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Immunoglobulin g pgt151 fab, light chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (39 kDa, Protein from Human immunodeficiency virus 1)
- Amc011 glycoprotein 120 (Complex from Human immunodeficiency virus 1)
- Amc011 glycoprotein 41 (Complex from Human immunodeficiency virus 1)
- Immunoglobulin g pgt151 fab, heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt151 fab (Complex from Homo sapiens)
BG505 SOSIP.664 trimer in complex with PGT124 Fab with 32H heavy chain
Garces F, Lee JH, de Val N, Torrents de la Pena A, Kong L, Puchades C, Hua Y, Stanfield R, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA
Immunity (2015) 43 pp. 1053-1063 [ Pubmed: 26682982 DOI: doi:10.1016/j.immuni.2015.11.007 ]
- Pgt124 32h+3l fab in complex with bg505 sosip.664 (570 MDa, Sample)
- Pgt124 fab with 32h heavy chain (50 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 env trimer (420 MDa, Protein)
BG505 SOSIP.664 N137A trimer in complex with PGT124 Fab with 3H heavy chain
Garces F, Lee JH, de Val N, Torrents de la Pena A, Kong L, Puchades C, Hua Y, Stanfield R, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA
Immunity (2015) 43 pp. 1053-1063 [ Pubmed: 26682982 DOI: doi:10.1016/j.immuni.2015.11.007 ]
- Pgt124 3h+3l fab in complex with bg505 sosip.664 n137a (570 MDa, Sample)
- Pgt124 antibody (50 MDa, Protein from Homo sapiens)
- Bg505 sosip.664 env trimer (420 MDa, Protein)
Negative stain EM reconstruction of HIV-1 Env AMC008 SOSIP.v4 in complex with Fabs 35O22 and PGV04
de Taeye SW, Ozorowski G, Torrents de la Pena A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW
Cell (2015) 163 pp. 1702-1715 [ Pubmed: 26687358 DOI: doi:10.1016/j.cell.2015.11.056 ]
- Anti-hiv-1 antibody 35o22 fab (50 kDa, Protein from Homo sapiens)
- Hiv-1 amc008 env sosip.v4 (420 kDa, Protein from Human immunodeficiency virus 1)
- Anti-hiv-1 antibody pgv04 fab (50 kDa, Protein from Homo sapiens)
- Hiv-1 env amc008 sosip.v4 in complex with broadly neutralizing antibody fabs 35o22 and pgv04 (720 kDa, Sample)