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Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 7t6x
Q-score: 0.381
Torrents de la Pena A, Sliepen K, Eshun-Wilson L, Newby ML, Allen JD, Zon I, Koekkoek S, Chumbe A, Crispin M, Schinkel J, Lander GC, Sanders RW, Ward AB
Science (2022) 378 pp. 263-269 [ DOI: doi:10.1126/science.abn9884 Pubmed: 36264808 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- At12009 crossmab, light kappa chain (24 kDa, Protein from Homo sapiens)
- Ar4a, kappa light chain (25 kDa, Protein from Homo sapiens)
- Igh505, heavy chain (52 kDa, Protein from Homo sapiens)
- Cryoem structure of full-length hepatitis c virus e1e2 glycoprotein in complex with ar4a, at12009 and igh505 fabs (Complex from Hepacivirus C)
- At12009 crossmab, heavy chain (29 kDa, Protein from Homo sapiens)
- Ar4a fab, heavy chain (29 kDa, Protein from Homo sapiens)
- Envelope glycoprotein e2 (40 kDa, Protein from Hepacivirus C)
- Envelope glycoprotein e1 (20 kDa, Protein from Hepacivirus C)
- Igh505, lambda light chain (24 kDa, Protein from Homo sapiens)
AMC009 SOSIPv5.2 in complex with Fabs ACS101 and ACS124
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 7zlk
Q-score: 0.362
van Schooten J, Schorcht A, Farokhi E, Umotoy JC, Gao H, van den Kerkhof TLGM, Dorning J, Rijkhold Meesters TG, van der Woude P, Burger JA, Bijl T, Ghalaiyini R, Torrents de la Pena A, Turner HL, Labranche CC, Stanfield RL, Sok D, Schuitemaker H, Montefiori DC, Burton DR, Ozorowski G, Seaman MS, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2022) 18 pp. e1010945-e1010945 [ DOI: doi:10.1371/journal.ppat.1010945 Pubmed: 36395347 ]
- Acs122 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc009 sosipv5.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Acs114 light chain (12 kDa, Protein from Homo sapiens)
- Acs114 heavy chain (13 kDa, Protein from Homo sapiens)
- Acs122 light chain (11 kDa, Protein from Homo sapiens)
- Amc009 sosipv5.2 in complex with fabs acs114 and acs122 (17 MDa, Complex from Human immunodeficiency virus 1)
- Amc009 sosipv5.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7scn
Q-score: 0.534
Sangesland M, Torrents de la Pena A, Boyoglu-Barnum S, Ronsard L, Mohamed FAN, Moreno TB, Barnes RM, Rohrer D, Lonberg N, Ghebremichael M, Kanekiyo M, Ward A, Lingwood D
Immunity (2022) 55 pp. 1693-1709.e8 [ DOI: doi:10.1016/j.immuni.2022.07.006 Pubmed: 35952670 ]
- Hemagglutinin ha2 chain (26 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- Hemagglutinin ha1 chain (35 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 310-63e6 fab, heavy chain (13 kDa, Protein from Homo sapiens)
- Structure of h1 nc99 influenza hemagglutinin bound to 310-63e6 fab (Complex from Influenza A virus)
- 310-63e6 fab, light chain (11 kDa, Protein from Homo sapiens)
Structure of H1 influenza hemagglutinin bound to Fab 310-39G10
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7sco
Q-score: 0.451
Sangesland M, Torrents de la Pena A, Boyoglu-Barnum S, Ronsard L, Mohamed FAN, Moreno TB, Barnes RM, Rohrer D, Lonberg N, Ghebremichael M, Kanekiyo M, Ward A, Lingwood D
Immunity (2022) 55 pp. 1693-1709.e8 [ DOI: doi:10.1016/j.immuni.2022.07.006 Pubmed: 35952670 ]
- Hemagglutinin ha2 chain (26 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- Hemagglutinin ha1 chain (35 kDa, Protein from Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 310-39g10 fab, light chain (11 kDa, Protein from Homo sapiens)
- 310-39g10 fab, heavy chain (12 kDa, Protein from Homo sapiens)
- Structure of h1 nc99 influenza hemagglutinin bound to fab 310-39g10 (Complex from Influenza A virus)
AMC009 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vo3
Q-score: 0.29
Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, Torrents de la Pena A, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW
J Virol (2020) 94 [ Pubmed: 32999024 DOI: doi:10.1128/JVI.01214-20 ]
- Amc009 sosip.v4.2 in complex with pgv04 fab (Complex)
- Amc009 sosip.v4.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgv04 heavy chain (24 kDa, Protein from Homo sapiens)
- Pgv04 light chain (23 kDa, Protein from Homo sapiens)
- Amc009 sosip.v4.2 (Complex from Human immunodeficiency virus 1)
- Amc009 sosip.v4.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 fab (Complex from Homo sapiens)
PGT145 Fab in complex with full length AMC011 HIV-1 Env
Resolution: 5.7 Å
EM Method: Single-particle
Fitted PDBs: 6nij
Q-score: 0.18
Torrents de la Pena A, Rantalainen K, Cottrell CA, Allen JD, van Gils MJ, Torres JL, Crispin M, Sanders RW, Ward AB
PLoS Pathog (2019) 15 pp. e1007920-e1007920 [ DOI: doi:10.1371/journal.ppat.1007920 Pubmed: 31306470 ]
- Amc011 glycoprotein 41 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt145 fab heavy chain (15 kDa, Protein from Homo sapiens)
- Pgt145 (Complex from Homo sapiens)
- Amc011 glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Amc011 glycoprotein 120 (Complex from Homo sapiens)
- Pgt145 fab light chain (12 kDa, Protein from Homo sapiens)
- Amc011 glycoprotein 41 (39 kDa, Protein from Human immunodeficiency virus 1)
- Pgt145 fab in complex with full length amc011 hiv-1 env (Complex)
Full length HIV-1 Env AMC011 in complex with PGT151 Fab
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6olp
Q-score: 0.399
Torrents de la Pena A, Rantalainen K, Cottrell CA, Allen JD, van Gils MJ, Torres JL, Crispin M, Sanders RW, Ward AB
PLoS Pathog (2019) 15 pp. e1007920-e1007920 [ DOI: doi:10.1371/journal.ppat.1007920 Pubmed: 31306470 ]
- Envelope glycoprotein gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Amc011 glycoprotein 120 (Complex from Human immunodeficiency virus 1)
- Immunoglobulin g pgt151 fab, heavy chain (26 kDa, Protein from Homo sapiens)
- Immunoglobulin g pgt151 fab, light chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt151 fab in complex with full length amc011 hiv-1 env (Complex)
- Pgt151 fab (Complex from Homo sapiens)
- Amc011 glycoprotein 41 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (39 kDa, Protein from Human immunodeficiency virus 1)