Do data resources managed by EMBL-EBI and our collaborators make a difference to your work? Please take 10 minutes to fill in our annual user survey, and help us make the case for why sustaining open data resources is critical for life sciences research.
Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8qxm
Q-score: 0.573
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8qxn
Q-score: 0.459
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8qxo
Q-score: 0.417
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Fe (iii) ion (55 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)