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Cryo-EM structure of human NTCP complexed with YN69202Fab
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 7vad
Q-score: 0.399
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Ntcp: (Complex from Mus musculus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Fab (Complex)
Cryo-EM structure of bovine NTCP complexed with YN69202Fab
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7vae
Q-score: 0.4
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (38 kDa, Protein from Bos taurus)
- Ntcp (Complex from Mus musculus)
- Fab (Complex)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of Rat NTCP complexed with YN69202Fab
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7vaf
Q-score: 0.461
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Rattus norvegicus)
- Complex of ntcp and fab (Complex from Mus musculus)
- Fab (Complex from Rattus norvegicus)
- Ntcp (Complex)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7vag
Q-score: 0.401
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Ntcp (Complex from Mus musculus)
- Complex of ntcp and fab in the presence of myristoylated pres1 peptide (Complex from Homo sapiens)
- Fab (Complex)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7wsi
Q-score: 0.434
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Fab (Complex)
- Ntcp (Complex from Homo sapiens)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of human TLR3 in complex with UNC93B1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7c76
Q-score: 0.437
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol (2021) 28 pp. 173-180 [ DOI: doi:10.1038/s41594-020-00542-w Pubmed: 33432245 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Toll-like receptor 3 (103 kDa, Protein from Homo sapiens)
- Protein unc-93 homolog b1 (66 kDa, Protein from Homo sapiens)
- Complex of tlr3 and unc93b1 (Complex from Homo sapiens)
Cryo-EM structure of mouse TLR3 in complex with UNC93B1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7c77
Q-score: 0.424
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol (2021) 28 pp. 173-180 [ DOI: doi:10.1038/s41594-020-00542-w Pubmed: 33432245 ]
- Toll-like receptor 3 (103 kDa, Protein from Mus musculus)
- Protein unc-93 homolog b1 (67 kDa, Protein from Mus musculus)
- Complex of tlr3 and unc93b1 (Complex from Mus musculoides)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human TLR7 in complex with UNC93B1
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7cyn
Q-score: 0.243
Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T
Nat Struct Mol Biol (2021) 28 pp. 173-180 [ DOI: doi:10.1038/s41594-020-00542-w Pubmed: 33432245 ]
- Complex of tlr7 and unc93b1 (Complex from Homo sapiens)
- Toll-like receptor 7 (121 kDa, Protein from Homo sapiens)
- Protein unc-93 homolog b1 (66 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7d7m
Q-score: 0.47
Nojima S, Fujita Y, Kimura KT, Nomura N, Suno R, Morimoto K, Yamamoto M, Noda T, Iwata S, Shigematsu H, Kobayashi T
Structure (2021) 29 pp. 252-260.e6 [ Pubmed: 33264604 DOI: doi:10.1016/j.str.2020.11.007 ]
- Prostaglandin e2 receptor ep4 subtype,guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype,prostaglandin e2 receptor ep4 subtype (36 kDa, Protein from Homo sapiens)
- Pge2-ep4-gs-gbeta1-ggamma2-nb35 complex (120 kDa, Complex)
- Nanobody nb35 (14 kDa, Protein from Lama glama)
- Nanobody nb35 (Complex from Lama glama)
Structure of a Group II Intron Complexed with its Reverse Transcriptase
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5g2x
Q-score: 0.158
Qu G, Kaushal PS, Wang J, Shigematsu H, Piazza CL, Agrawal RK, Belfort M, Wang HW
Nat Struct Mol Biol (2016) 23 pp. 549-557 [ DOI: doi:10.1038/NSMB.3220 Pubmed: 27136327 ]