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Structure of human TRPML1 with ML-SI3
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7mgl
Q-score: 0.558
Structure (2021) 29 pp. 1295-1302.e3 [ DOI: doi:10.1016/j.str.2021.06.003 Pubmed: 34171299 ]
- Mucolipin-1 (65 kDa, Protein from Homo sapiens)
- N-{(1s,2s)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide (429 Da, Ligand)
- Trpml1 complex with ml-si3 (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
cryo-EM structure of human TRPML1 with PI35P2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6e7p
Q-score: 0.447
Nat Commun (2018) 9 pp. 4192-4192 [ DOI: doi:10.1038/s41467-018-06493-7 Pubmed: 30305615 ]
cryo-EM structure of human TRPML1 with PI45P2
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 6e7y
Q-score: 0.431
Nat Commun (2018) 9 pp. 4192-4192 [ DOI: doi:10.1038/s41467-018-06493-7 Pubmed: 30305615 ]
cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 6e7z
Q-score: 0.392
Nat Commun (2018) 9 pp. 4192-4192 [ DOI: doi:10.1038/s41467-018-06493-7 Pubmed: 30305615 ]
- Trpml1 (Complex from Homo sapiens)
- (1r,2s,3s,4r,5s,6r)-5-{[(r)-[(2r)-2,3-bis{[(1s)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)] (750 Da, Ligand)
- 2-{2-oxo-2-[(4s)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2h)-yl]ethyl}-1h-isoindole-1,3(2h)-dione (362 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Homo sapiens)
Structure of 2:1 human Ptch1-Shh-N complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6e1h
Q-score: 0.394
Qi X, Schmiege P, Coutavas E, Li X
Science (2018) 362 [ Pubmed: 30139912 DOI: doi:10.1126/science.aas8843 ]
- Protein patched homolog 1 (160 kDa, Protein from Homo sapiens)
- Sonic hedgehog protein (19 kDa, Protein from Homo sapiens)
- Ptc (265 kDa, Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6oeu
Q-score: 0.393
Qi X, Schmiege P, Coutavas E, Wang J, Li X
Nature (2018) 560 pp. 128-132 [ DOI: doi:10.1038/s41586-018-0308-7 Pubmed: 29995851 ]
- N-acetyl-d-glucosamine (221 Da, Ligand)
- Protein patched homolog 1 (161 kDa, Protein from Homo sapiens)
- Ptc (121 kDa, Complex from Homo sapiens)
Human TRPML1 channel structure in closed conformation
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 5wj5
Q-score: 0.322
Schmiege P, Fine M, Blobel G, Li X
Nature (2017) 550 pp. 366-370 [ DOI: doi:10.1038/nature24036 Pubmed: 29019983 ]
- Trpml1 (Complex from Homo sapiens)
- Mucolipin-1 (65 kDa, Protein from Homo sapiens)
Human TRPML1 channel structure in agonist-bound open conformation
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 5wj9
Q-score: 0.342
Schmiege P, Fine M, Blobel G, Li X
Nature (2017) 550 pp. 366-370 [ DOI: doi:10.1038/nature24036 Pubmed: 29019983 ]
- Trpml1 (Complex from Homo sapiens)
- 2-{2-oxo-2-[(4s)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2h)-yl]ethyl}-1h-isoindole-1,3(2h)-dione (362 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Homo sapiens)