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Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-P2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ayj
Q-score: 0.484
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 3,5-dichloro-n-[(1-{[(4s)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide (431 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ML218
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayk
Q-score: 0.519
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 3,5-dichloro-n-{[(1r,5s,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide (369 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ACT-709478
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9ayl
Q-score: 0.531
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) 34 pp. 440-450 [ Pubmed: 38605177 DOI: doi:10.1038/s41422-024-00959-8 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- N-{1-[(5-cyanopyridin-2-yl)methyl]-1h-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide (425 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)