Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7upw
Q-score: 0.464
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7upx
Q-score: 0.513
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (local refinement of the rbd and fab variable domains) (6 MDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7upy
Q-score: 0.384
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- One rbd-up state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Sp1-77 antibody fab light chain, sp1-77 antibody fab heavy chain (Complex from Mus musculus)
- Complex of sars-cov2 2p spike with sp1-77 antibody fab (48 kDa, Complex)
- Sp1-77 antibody fab light chain (Protein from Mus musculus)
- Sp1-77 antibody fab heavy chain (Protein from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Vhh7-7-53 antibody fab light chain, vhh7-7-53 antibody fab heavy chain (Complex from Mus musculus)
- Complex of sars-cov2 2p spike with vhh7-7-53 antibody fab (48 kDa, Complex)
- Vhh7-7-53 antibody heavy chain (Protein from Mus musculus)
- Vhh7-7-53 antibody light chain (Protein from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with vhh7-5-82 antibody fab (48 kDa, Complex)
- Vhh7-5-82 antibody fab light chain (Protein from Mus musculus)
- Vhh7-5-82 antibody fab light chain, vhh7-5-82 antibody fab heavy chain (Complex from Mus musculus)
- Vhh7-5-82 antibody fab heavy chain (Protein from Mus musculus)