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Human TRiC-PhLP2A complex in the closed state
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8i1u
Q-score: 0.506
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Phlp2a (pdcl3) (Complex)
- Human tric/cct complex (Complex from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- Complex of tric/cct-phlp2a treated with atp-alfx (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- Aluminum fluoride (83 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
The focused refinement of CCT3-PhLP2A from TRiC-PhLP2A complex in the open state
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 8i6j
Q-score: 0.404
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Complex of tric/cct and phlp2a (1 MDa, Complex from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Tric/cct (Complex)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
Human TRiC-PhLP2A complex in the open state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8i9u
Q-score: 0.286
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Phlp2a (pdcl3) in human tric/cct complex (Complex from Homo sapiens)
- Human tric/cct complex (Complex from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- Complex of human tric/cct and phlp2a (1 MDa, Complex)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
The focused refinement of CCT4-PhLP2A from TRiC-PhLP2A complex in the open state
Resolution: 4.22 Å
EM Method: Single-particle
Fitted PDBs: 8i9q
Q-score: 0.318
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- T-complex protein 1 subunit delta from human tric/cct complex (Complex from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- Complex of human tric/cct-phlp2a (1 MDa, Complex)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
Human TRiC-PhLP2A-actin complex in the closed state
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 8ib8
Q-score: 0.271
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Complex of tric/cct, phlp2a, and actin treated with atp-alfx (1 MDa, Complex)
- Human tric/cct complex (Complex from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- Human actin (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Actb protein (fragment) (41 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
EM structure of endogenous TREX complex from S. cerevisiae
Kern C, Radon C, Wende W, Leitner A, Strasser K
RNA (2023) 29 pp. 1870-1880 [ Pubmed: 37699651 DOI: doi:10.1261/rna.079758.123 ]
Sodium pumping NADH-quinone oxidoreductase with substrates NADH and Q2
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8a1u
Q-score: 0.558
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ DOI: doi:10.1038/s41594-023-01099-0 Pubmed: 37710014 ]
- Flavin mononucleotide (456 Da, Ligand)
- Water (18 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Riboflavin (376 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Nqr complex with substrates nadh and q2 (220 kDa, Complex from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Ubiquinone-2 (318 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8a1t
Q-score: 0.452
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ DOI: doi:10.1038/s41594-023-01099-0 Pubmed: 37710014 ]
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Potassium ion (39 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Nqr complex (220 kDa, Complex from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit a (48 kDa, Protein from Vibrio cholerae)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Riboflavin (376 Da, Ligand)
Sodium pumping NADH-quinone oxidoreductase with substrate Q2
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8a1v
Q-score: 0.54
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ DOI: doi:10.1038/s41594-023-01099-0 Pubmed: 37710014 ]
- Flavin mononucleotide (456 Da, Ligand)
- Water (18 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Riboflavin (376 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Ubiquinone-2 (318 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
- Nqr complex with substrate q2 (220 kDa, Complex from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase with substrate Q1
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8a1w
Q-score: 0.555
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ DOI: doi:10.1038/s41594-023-01099-0 Pubmed: 37710014 ]
- Flavin mononucleotide (456 Da, Ligand)
- Water (18 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Riboflavin (376 Da, Ligand)
- Nqr complex with substrate q1 (220 kDa, Complex from Vibrio cholerae)
- Ubiquinone-1 (250 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)