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Structure of a class A GPCR/Fab complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tlm
Q-score: 0.527
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
- Ccr8_fab complex (Complex from Homo sapiens)
- Fab light chain (23 kDa, Protein from Oryctolagus cuniculus)
- Fab heavy chain (23 kDa, Protein from Oryctolagus cuniculus)
- C-c chemokine receptor type 8, green fluorescent protein fusion (76 kDa, Protein from Aequorea victoria)
Structure of a class A GPCR/agonist complex (focused map2)
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
Structure of a class A GPCR/agonist complex (focused map1)
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
Structure of a class A GPCR/agonist complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8u1u
Q-score: 0.515
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (43 kDa, Protein from Homo sapiens)
- C-c motif chemokine 1,c-c chemokine receptor type 8,egfp fusion protein (83 kDa, Protein from Human adenovirus C serotype 2)
- Ccr8 in complex with ccl1 and gi (Complex from Homo sapiens)
- Scfv fragment (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Structure of a class A GPCR/agonist complex (Consensus map)
Sun D, Sun Y, Janezic E, Zhou T, Johnson M, Azumaya C, Noreng S, Chiu C, Seki A, Arenzana TL, Nicoludis JM, Shi Y, Wang B, Ho H, Joshi P, Tam C, Payandeh J, Comps-Agrar L, Wang J, Rutz S, Koerber JT, Masureel M
Nat Commun (2023) 14 pp. 7940-7940 [ Pubmed: 38040762 DOI: doi:10.1038/s41467-023-43601-8 ]
Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8c1p
Q-score: 0.561
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Cyclothiazide (389 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8c1q
Q-score: 0.54
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c1r
Q-score: 0.55
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- Homomeric glua2 f231a mutant ampa receptor in complex with tarp gamma 2 (Complex from Rattus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8c1s
Q-score: 0.556
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- Homomeric glua2 f231a mutant ampa receptor in complex with tarp gamma 2 (Complex from Rattus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8c2h
Q-score: 0.619
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Palmitic acid (256 Da, Ligand)
- Water (18 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)