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Cryo-EM structure of human NCX1 in complex with SEA0400
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8sgi
Q-score: 0.553
To Be Published
- Sodium ion (22 Da, Ligand)
- Human ncx1-sea0400 in complex with antibody fab fragment (Complex)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline (371 Da, Ligand)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Antibody fab fragment (Complex from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
- Human cardiac sodium calcium exchanger ncx1 in complex with sea0400 (Complex from Homo sapiens)
Cryo-EM structure of OSCA3.1-GDN state
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8xw0
Q-score: 0.516
Cryo-EM structure of human NCX1 in apo inactivated state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sgj
Q-score: 0.499
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Sodium ion (22 Da, Ligand)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Human cardiac ncx1 in apo inactivated state (Complex from Homo sapiens)
- Human cardiac ncx1 in complex with antibody fab fragment (Complex)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Antibody fab fragment (Complex from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ffz
Q-score: 0.333
Talyzina A, Han Y, Banerjee C, Fishbain S, Reyes A, Vafabakhsh R, He Y
Mol Cell (2023) 83 pp. 2641- [ DOI: doi:10.1016/j.molcel.2023.06.015 Pubmed: 37402369 ]
- Transcription factor tau 131 kda subunit (120 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 95 kda subunit (73 kDa, Protein from Saccharomyces cerevisiae)
- Dna (151-mer) (52 kDa, DNA from Saccharomyces cerevisiae)
- Transcription factor tau 138 kda subunit (132 kDa, Protein from Saccharomyces cerevisiae)
- Tfiiia-tfiiic-brf1-tbp complex bound to 5srrna gene (810 MDa, Complex from Saccharomyces cerevisiae)
- Transcription factor iiia (52 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 55 kda subunit (49 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor iiib 70 kda subunit,tata-box-binding protein (82 kDa, Protein from Saccharomyces cerevisiae S288C)
- Zinc ion (65 Da, Ligand)
- Transcription factor tau 60 kda subunit (67 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 91 kda subunit (74 kDa, Protein from Saccharomyces cerevisiae)
- Dna (151-mer) (52 kDa, DNA from Saccharomyces cerevisiae)
Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution
Resolution: 2.32 Å
EM Method: Single-particle
Fitted PDBs: 7sq6
Q-score: 0.659
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- 2-{2-oxo-2-[(4s)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2h)-yl]ethyl}-1h-isoindole-1,3(2h)-dione (362 Da, Ligand)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 7sq7
Q-score: 0.627
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Sodium ion (22 Da, Ligand)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution
Resolution: 2.598 Å
EM Method: Single-particle
Fitted PDBs: 7sq8
Q-score: 0.618
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 7sq9
Q-score: 0.69
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Sodium ion (22 Da, Ligand)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- (1r,2r,4s)-4-{(2r)-2-[(3s,6r,7e,9r,10r,12r,14s,15e,17e,19e,21s,23s,26r,27r,30s,34as)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3h-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate (1 kDa, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 7rhg
Q-score: 0.602
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
- Human rod cnga1/b1 channel in camp-bound state (Complex from Homo sapiens)
- Adenosine-3',5'-cyclic-monophosphate (329 Da, Ligand)
Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 7rhh
Q-score: 0.51
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
- Human rod cnga1/b1 channel in cgmp-bound openi state (Complex from Homo sapiens)