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Structure of human ASCT1 transporter
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7p4i
Q-score: 0.279
Stehantsev P, Stetsenko A, Nemchinova M, Aduri NG, Marrink SJ, Gati C, Guskov A
Comput Struct Biotechnol J (2021) 19 pp. 5246-5254 [ DOI: doi:10.1016/j.csbj.2021.09.015 ]
- Trimeric asct1 transporter (167 kDa, Complex from Homo sapiens)
- Neutral amino acid transporter a (55 kDa, Protein from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 6rvx
Q-score: 0.488
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) in absence of substrate
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- Asct2 (Protein from Homo sapiens)
- Asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 6rvy
Q-score: 0.369
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
cryo-EM structure of the human neutral amino acid transporter ASCT2
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6gct
Q-score: 0.424
Garaeva AA, Oostergetel GT, Gati C, Guskov A, Paulino C, Slotboom DJ
Nat Struct Mol Biol (2018) 25 pp. 515-521 [ DOI: doi:10.1038/s41594-018-0076-y Pubmed: 29872227 ]
- Human asct2 slc1a5 (172 kDa, Complex from Homo sapiens)
- Neutral amino acid transporter b(0) (56 kDa, Protein from Homo sapiens)
- Glutamine (146 Da, Ligand)