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Cryo-EM structure of adenosine receptor A3AR bound to CF101
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8x16
Q-score: 0.31
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE
Nat Commun (2024) 15 pp. 3252-3252 [ DOI: doi:10.1038/s41467-024-47207-6 Pubmed: 38627384 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Piclidenoson (510 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G protein (Complex from Rattus norvegicus)
- Adenosine receptor a3 (36 kDa, Protein from Homo sapiens)
- G protein (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
- Scfv16 (Complex from Mus musculus)
- Cryo-em structure of adenosine receptor a3ar bound to cf101 (160 kDa, Complex)
- A3ar (Complex from Homo sapiens)
Cryo-EM structure of adenosine receptor A3AR bound to CF102
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8x17
Q-score: 0.473
Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE
Nat Commun (2024) 15 pp. 3252-3252 [ DOI: doi:10.1038/s41467-024-47207-6 Pubmed: 38627384 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- A3ar (Complex from Rattus norvegicus)
- Cryo-em structure of adenosine receptor a3ar bound to cf102 (160 kDa, Complex)
- Adenosine receptor a3 (36 kDa, Protein from Homo sapiens)
- G protein (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Namodenoson (544 Da, Ligand)
- G protein (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Bos taurus)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8hp9
Q-score: 0.368
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ Pubmed: 37507370 DOI: doi:10.1038/s41421-023-00585-5 ]
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.2 s-trimer in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8hpq
Q-score: 0.243
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ Pubmed: 37507370 DOI: doi:10.1038/s41421-023-00585-5 ]
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Spike protein s2' (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.4 s-trimer in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with fab L4.65 and L5.34
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 8hpf
Q-score: 0.494
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ Pubmed: 37507370 DOI: doi:10.1038/s41421-023-00585-5 ]
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.2 rbd in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8hpu
Q-score: 0.488
Guo S, Zheng Y, Gao Z, Duan M, Liu S, Du P, Xu X, Xu K, Zhao X, Chai Y, Wang P, Zhao Q, Gao GF, Dai L
Cell Discov (2023) 9 pp. 79-79 [ Pubmed: 37507370 DOI: doi:10.1038/s41421-023-00585-5 ]
- Fab l4.65 (24 kDa, Protein from Homo sapiens)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of sars-cov-2 omicron ba.4 rbd in complex with fab l4.65 and l5.34 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab l4.65 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- Fab l5.34 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
T1AM-bound mTAAR1-Gs protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jlj
Q-score: 0.543
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mgs (41 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
- T1am-bound htaar1 (Complex from Mus musculus)
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jlk
Q-score: 0.387
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mgs (41 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- T1am-bound htaar1 (Complex from Mus musculus)
T1AM-bound hTAAR1-Gs protein complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8jln
Q-score: 0.427
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mgs (43 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
- T1am-bound htaar1 (Complex from Homo sapiens)
Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8jlo
Q-score: 0.473
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Htaar1-bound sep363856 in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Sep-bound htaar1 (Complex from Homo sapiens)