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Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7xkd
Q-score: 0.563
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X
Nat Chem Biol (2022) 18 pp. 1196-1203 [ DOI: doi:10.1038/s41589-022-01084-6 Pubmed: 35982227 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Mus musculus)
- Adhesion g-protein (Complex from Camelus bactrianus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (34 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (Complex)
- 3-beta-hydroxy-5-androsten-17-one (288 Da, Ligand)
- Nb35 (13 kDa, Protein from Camelus bactrianus)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (130 kDa, Complex from Homo sapiens)
Cryo-EM structure of DHEA-ADGRG2-FL-Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xke
Q-score: 0.532
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X
Nat Chem Biol (2022) 18 pp. 1196-1203 [ DOI: doi:10.1038/s41589-022-01084-6 Pubmed: 35982227 ]
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (220 kDa, Complex from Mus musculus)
- Adhesion g-protein coupled receptor g2 (98 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 3-beta-hydroxy-5-androsten-17-one (288 Da, Ligand)
- Nb35 (13 kDa, Protein from Camelus bactrianus)
- Water (18 Da, Ligand)
Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex at lower state
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7xkf
Q-score: 0.563
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X
Nat Chem Biol (2022) 18 pp. 1196-1203 [ DOI: doi:10.1038/s41589-022-01084-6 Pubmed: 35982227 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Mus musculus)
- Adhesion g-protein (Complex from Camelus bactrianus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Receptor g2 (Complex)
- 3-beta-hydroxy-5-androsten-17-one (288 Da, Ligand)
- Adhesion g-protein coupled receptor g2 (34 kDa, Protein from Mus musculus)
- Nb35 (13 kDa, Protein from Camelus bactrianus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (130 kDa, Complex from Homo sapiens)