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10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gje
Q-score: 0.451
Ringe RP, Colin P, Ozorowski G, Allen JD, Yasmeen A, Seabright GE, Lee JH, Antanasijevic A, Rantalainen K, Ketas T, Moore JP, Ward AB, Crispin M, Klasse PJ
PLoS Pathog (2023) 19 pp. e1011601-e1011601 [ DOI: doi:10.1371/journal.ppat.1011601 Pubmed: 37903160 ]
- 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Cza97.12 sosip.664 envelope glycoprotein gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- 3bnc117 kappa light chain (23 kDa, Protein from Homo sapiens)
- Cza97.12 sosip.664 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cza97.12 sosip.664 in complex with 3bnc117 fab (570 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8ejh
Q-score: 0.406
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- 12.1f fab heavy chain (13 kDa, Protein from Homo sapiens)
- 12.1f fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Alpha-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to 19.7E Fab
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8eji
Q-score: 0.39
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- 19.7e fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (325 kDa, Complex from Lassa mammarenavirus)
- 19.7e fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8ejj
Q-score: 0.506
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- S370.7 light chain fab (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)
- S370.7 heavy chain fab (14 kDa, Protein from Homo sapiens)
Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 7t6x
Q-score: 0.381
Torrents de la Pena A, Sliepen K, Eshun-Wilson L, Newby ML, Allen JD, Zon I, Koekkoek S, Chumbe A, Crispin M, Schinkel J, Lander GC, Sanders RW, Ward AB
Science (2022) 378 pp. 263-269 [ DOI: doi:10.1126/science.abn9884 Pubmed: 36264808 ]
- Envelope glycoprotein e1 (20 kDa, Protein from Hepacivirus C)
- At12009 crossmab, light kappa chain (24 kDa, Protein from Homo sapiens)
- Cryoem structure of full-length hepatitis c virus e1e2 glycoprotein in complex with ar4a, at12009 and igh505 fabs (Complex from Hepacivirus C)
- Ar4a fab, heavy chain (29 kDa, Protein from Homo sapiens)
- Igh505, heavy chain (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igh505, lambda light chain (24 kDa, Protein from Homo sapiens)
- Ar4a, kappa light chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein e2 (40 kDa, Protein from Hepacivirus C)
- At12009 crossmab, heavy chain (29 kDa, Protein from Homo sapiens)
HIV-1 Envelope ApexGT2.2MUT in complex with PCT64.LMCA Fab
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7t73
Q-score: 0.388
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ DOI: doi:10.1016/j.immuni.2022.09.001 Pubmed: 36179689 ]
- Hiv envelope apexgt2.2mut gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Hiv envelope apexgt2.2mut gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt2.2mut in complex with pct64.lmca fab (Complex from Human immunodeficiency virus 1)
- Pct64.lmca fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pct64.lmca fab heavy chain (25 kDa, Protein from Homo sapiens)
HIV-1 Envelope ApexGT2 in complex with PCT64.35S Fab and RM20A3 Fab
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7t74
Q-score: 0.476
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ DOI: doi:10.1016/j.immuni.2022.09.001 Pubmed: 36179689 ]
- Pct64.35s fab light chain (11 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt2 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Pct64.35s fab heavy chain (14 kDa, Protein from Homo sapiens)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Hiv-1 envelope apexgt2 in complex with pct64.35 fab and rm20a3 fab (Complex from Human immunodeficiency virus 1)
- Hiv envelope apexgt2 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
HIV-1 Envelope ApexGT2 in complex with RM20A3 Fab
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7t75
Q-score: 0.58
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ DOI: doi:10.1016/j.immuni.2022.09.001 Pubmed: 36179689 ]
- Rm20a3 fab light chain (13 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt2 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Hiv envelope apexgt2 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Hiv-1 envelope apexgt2 in complex with rm20a3 fab (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
HIV-1 Envelope ApexGT3 in complex with PG9.iGL Fab
Resolution: 4.43 Å
EM Method: Single-particle
Fitted PDBs: 7t76
Q-score: 0.324
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates 3rd JR, Paulson JC, Crispin M, Ward AB, Schief WR
Immunity (2022) 55 pp. 2149- [ DOI: doi:10.1016/j.immuni.2022.09.001 Pubmed: 36179689 ]
- Pg9.igl fab light chain (28 kDa, Protein from Homo sapiens)
- Hiv envelope apexgt3 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt3 in complex with pg9.igl fab (Complex from Human immunodeficiency virus 1)
- Hiv envelope apexgt3 gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
- Pg9.igl fab heavy chain (28 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)