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Gradient-fixed lipidated recombinant apolipoprotein E4
Strickland MR, Rau MJ, Summers B, Basore K, Wulf 2nd J, Jiang H, Chen Y, Ulrich JD, Randolph GJ, Zhang R, Fitzpatrick JAJ, Cashikar AG, Holtzman DM
Neuron (2024) 112 pp. 1100-1109.e5 [ Pubmed: 38266643 DOI: doi:10.1016/j.neuron.2023.12.018 ]
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8ttw
Q-score: 0.507
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ Pubmed: 37872202 DOI: doi:10.1038/s41467-023-42500-2 ]
- Antibody 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Antibody 8anc195 heavy chain (25 kDa, Protein from Homo sapiens)
- Antibody 8anc195 light chain (23 kDa, Protein from Homo sapiens)
- Antibody 10-1074 heavy chain (25 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione (473 Da, Ligand)
- Complex of bg505 sosip.664 with temsavir and the antibody fabs of 8anc195 and 10-1074 (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8czz
Q-score: 0.428
Prevost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M
Nat Commun (2023) 14 pp. 6710-6710 [ Pubmed: 37872202 DOI: doi:10.1038/s41467-023-42500-2 ]
- Light chain of 8anc195 fab (23 kDa, Protein from Homo sapiens)
- Light chain of 10-1074 fab (23 kDa, Protein from Homo sapiens)
- Crf-1_ae t/f100 hiv-1 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1h-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione (473 Da, Ligand)
- Crf01_ae t/f100 hiv-1 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of 8anc195 fab (25 kDa, Protein from Homo sapiens)
- Cryo-em structure of t/f100 sosip.664 hiv-1 env trimer with lmhs mutations in complex with temsavir, 8anc195, and 10-1074 (6 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 10-1074 fab (25 kDa, Protein from Homo sapiens)
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 7rq6
Q-score: 0.33
Beaudoin-Bussieres G, Chen Y, Ullah I, Prevost J, Tolbert WD, Symmes K, Ding S, Benlarbi M, Gong SY, Tauzin A, Gasser R, Chatterjee D, Vezina D, Goyette G, Richard J, Zhou F, Stamatatos L, McGuire AT, Charest H, Roger M, Pozharski E, Kumar P, Mothes W, Uchil PD, Pazgier M, Finzi A
Cell Rep (2022) 38 pp. 110368-110368 [ DOI: doi:10.1016/j.celrep.2022.110368 Pubmed: 35123652 ]
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cv3-13 fab light chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 spike in complex with non-neutralizing, ntd-directed human antibody cv3-13 (670 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Cv3-13 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)