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Structure of human cGAS (K394E) bound to the nucleosome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6y5d
Q-score: 0.195
Pathare GR, Decout A, Gluck S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thoma NH, Ablasser A
Nature (2020) 587 pp. 668-672 [ DOI: doi:10.1038/s41586-020-2750-6 Pubmed: 32911482 ]
- Protein (Complex from Homo sapiens)
- Histone h2b type 1-k (13 kDa, Protein from Homo sapiens)
- Cryo-em structure of cgas-ncp complex (240 kDa, Complex)
- Histone h2a type 2-a (Complex from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (153-mer) (47 kDa, DNA from Homo sapiens)
- Histone h2a type 2-a (14 kDa, Protein from Homo sapiens)
- Pentanedial (100 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cyclic gmp-amp synthase (42 kDa, Protein from Homo sapiens)
- Dna (153-mer) (46 kDa, DNA from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Histone h3.2 (11 kDa, Protein from Homo sapiens)
Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 6y5e
Q-score: 0.43
Pathare GR, Decout A, Gluck S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thoma NH, Ablasser A
Nature (2020) 587 pp. 668-672 [ DOI: doi:10.1038/s41586-020-2750-6 Pubmed: 32911482 ]
- Protein (Complex from Homo sapiens)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Dna (153-mer) (46 kDa, DNA from Homo sapiens)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Dna (153-mer) (47 kDa, DNA from Homo sapiens)
- Pentanedial (100 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cryo em structure of cgas-ncp1 complex (240 kDa, Complex)
- Histone h2a type 2-c (11 kDa, Protein from Homo sapiens)
- Cyclic gmp-amp synthase (42 kDa, Protein from Homo sapiens)
- Histone h2a type 2-c (11 kDa, Protein from Homo sapiens)
- Histone h4 (Complex from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Histone h3.2 (11 kDa, Protein from Homo sapiens)
Structure of human cGAS bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)
Pathare GR, Decout A, Gluck S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thoma NH, Ablasser A
Nature (2020) 587 pp. 668-672 [ DOI: doi:10.1038/s41586-020-2750-6 Pubmed: 32911482 ]
- Dna (153-mer) (RNA from Homo sapiens)
- Histone h3.2 (Protein from Homo sapiens)
- Histone h4 (Protein from Homo sapiens)
- Histone h2b type 1-k (Protein from Homo sapiens)
- Cryo em structure of cgas-ncp1 complex (240 kDa, Complex)
- Cyclic gmp-amp synthase (Protein from Homo sapiens)
- Cryo em structure of cgas-ncp1 complex (Complex from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Histone h2a type 2-c (Protein from Homo sapiens)
- Dna (153-mer) (Protein from Homo sapiens)
Structure of human cGAS bound to the nucleosome
Pathare GR, Decout A, Gluck S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thoma NH, Ablasser A
Nature (2020) 587 pp. 668-672 [ DOI: doi:10.1038/s41586-020-2750-6 Pubmed: 32911482 ]
- Dna (153-mer) (RNA from Homo sapiens)
- Cyclic gmp-amp synthase (RNA from Homo sapiens)
- Histone h3.2 (Protein from Homo sapiens)
- Histone h4 (Protein from Homo sapiens)
- Histone h2b type 1-k (Protein from Homo sapiens)
- Cryo em structure of cgas-ncp1 complex (240 kDa, Complex)
- Cryo em structure of cgas-ncp1 complex (Complex from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Histone h2a type 2-c (Protein from Homo sapiens)
OCT4-SOX2-bound nucleosome - SHL-6
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 6t90
Q-score: 0.451
Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schubeler D, Thoma NH
Science (2020) 368 pp. 1460-1465 [ Pubmed: 32327602 DOI: doi:10.1126/science.abb0074 ]
- Dna (146-mer) (46 kDa, DNA from synthetic construct)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h2b type 1-j (14 kDa, Protein from Homo sapiens)
- Dna (Complex from synthetic construct)
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
- Pentanedial (100 Da, Ligand)
- Ternary complex of oct4-sox2 and shl-6 nucleosome (Complex)
- Histones (Complex from Homo sapiens)
- G protein/gfp fusion protein,pou domain, class 5, transcription factor 1 (oct4) (Complex from Homo sapiens)
- Sox2 (Complex from Homo sapiens)
- Transcription factor sox-2 (12 kDa, Protein from Homo sapiens)
- Green fluorescent protein,pou domain, class 5, transcription factor 1 (70 kDa, Protein from Homo sapiens)
Nucleosome with OCT4-SOX2 motif at SHL-6
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 6t93
Q-score: 0.419
Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schubeler D, Thoma NH
Science (2020) 368 pp. 1460-1465 [ Pubmed: 32327602 DOI: doi:10.1126/science.abb0074 ]
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histones (Complex from Homo sapiens)
- Dna (Complex from synthetic construct)
- Dna (153-mer) (47 kDa, DNA from synthetic construct)
- Histone h2b type 1-j (14 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
- Dna (153-mer) (46 kDa, DNA from synthetic construct)
- Ternary complex of oct4-sox2 and shl+6 nucleosome (Complex)
OCT4-SOX2-bound nucleosome - SHL+6
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 6yov
Q-score: 0.35
Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schubeler D, Thoma NH
Science (2020) 368 pp. 1460-1465 [ Pubmed: 32327602 DOI: doi:10.1126/science.abb0074 ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Green fluorescent protein,pou domain, class 5, transcription factor 1 (Complex from Homo sapiens)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Histone h2b type 1-j (14 kDa, Protein from Homo sapiens)
- Dna (Complex from synthetic construct)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Green fluorescent protein,pou domain, class 5, transcription factor 1 (69 kDa, Protein from Homo sapiens)
- Sox2 (Complex from Homo sapiens)
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
- Pentanedial (100 Da, Ligand)
- Dna (142-mer) (92 kDa, DNA from synthetic construct)
- Histones (Complex from Homo sapiens)
- Ternary complex of oct4-sox2 and shl+6 nucleosome (Complex)
- Transcription factor sox-2 (12 kDa, Protein from Homo sapiens)