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The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8ijq
Q-score: 0.461
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8ijr
Q-score: 0.485
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024) [ Pubmed: 38388831 DOI: doi:10.1038/s41594-024-01237-2 ]
- The cryo-em structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine (Complex from Homo sapiens)
- Phosphoric acid mono-(2-amino-ethyl) ester (141 Da, Ligand)
- Sphingomyelin synthase-related protein 1 (48 kDa, Protein from Homo sapiens)
- (2s)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11z)-octadec-11-enoate (594 Da, Ligand)
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8w9w
Q-score: 0.377
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024) [ Pubmed: 38388831 DOI: doi:10.1038/s41594-024-01237-2 ]
- The cryo-em structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine (Complex from Homo sapiens)
- Sphingomyelin synthase-related protein 1 (31 kDa, Protein from Homo sapiens)
- ~{n}-[(~{z},2~{s},3~{r})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide (467 Da, Ligand)
- Phosphoric acid mono-(2-amino-ethyl) ester (141 Da, Ligand)
The cryo-EM structure of human sphingomyelin synthase-related protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8w9y
Q-score: 0.392
The cryo-EM structure of human ERAD retro-translocation complex
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 7y4w
Q-score: 0.367
Rao B, Wang Q, Yao D, Xia Y, Li W, Xie Y, Li S, Cao M, Shen Y, Qin A, Zhao J, Cao Y
Sci Adv (2023) 9 pp. eadi5656-eadi5656 [ Pubmed: 37831771 DOI: doi:10.1126/sciadv.adi5656 ]
- The cryo-em structure of human erad retro-translocation complex (650 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (87 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Derlin-1 (26 kDa, Protein from Homo sapiens)
The cryo-EM structure of human ERAD retro-translocation complex
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7y53
Q-score: 0.366
Rao B, Wang Q, Yao D, Xia Y, Li W, Xie Y, Li S, Cao M, Shen Y, Qin A, Zhao J, Cao Y
Sci Adv (2023) 9 pp. eadi5656-eadi5656 [ Pubmed: 37831771 DOI: doi:10.1126/sciadv.adi5656 ]
- The cryo-em structure of human erad retro-translocation complex (650 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (87 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Derlin-1 (26 kDa, Protein from Homo sapiens)
The cryo-EM structure of human ERAD retro-translocation complex
Resolution: 4.51 Å
EM Method: Single-particle
Fitted PDBs: 7y59
Q-score: 0.22
Rao B, Wang Q, Yao D, Xia Y, Li W, Xie Y, Li S, Cao M, Shen Y, Qin A, Zhao J, Cao Y
Sci Adv (2023) 9 pp. eadi5656-eadi5656 [ Pubmed: 37831771 DOI: doi:10.1126/sciadv.adi5656 ]
- Transitional endoplasmic reticulum atpase (87 kDa, Protein from Homo sapiens)
- Derlin-1 (30 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- The cryo-em structure of human erad retro-translocation complex (650 kDa, Complex from Homo sapiens)
The cryo-EM structure of hAE2 with DIDS
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8gv8
Q-score: 0.555
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ Pubmed: 37002221 DOI: doi:10.1038/s41467-023-37557-y ]
- Hae2 with dids (137 kDa, Complex from Homo sapiens)
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
- 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid} (464 Da, Ligand)
The cryo-EM structure of hAE2 with chloride ion
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8gv9
Q-score: 0.549
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ Pubmed: 37002221 DOI: doi:10.1038/s41467-023-37557-y ]
- Chloride ion (35 Da, Ligand)
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
- Anion exchange protein 2 with chloride ion (137 kDa, Complex from Homo sapiens)
The intermediate structure of hAE2 in basic pH
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8gva
Q-score: 0.519
Zhang Q, Jian L, Yao D, Rao B, Xia Y, Hu K, Li S, Shen Y, Cao M, Qin A, Zhao J, Cao Y
Nat Commun (2023) 14 pp. 1812-1812 [ Pubmed: 37002221 DOI: doi:10.1038/s41467-023-37557-y ]
- Anion exchange protein 2 (137 kDa, Protein from Homo sapiens)
- Anion exchange protein 2 (137 kDa, Complex from Homo sapiens)